ID I2H519_TETBL Unreviewed; 963 AA.
AC I2H519;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=TBLA0E04160 {ECO:0000313|EMBL:CCH61471.1};
GN ORFNames=TBLA_0E04160 {ECO:0000313|EMBL:CCH61471.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH61471.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH61471.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE806320; CCH61471.1; -; Genomic_DNA.
DR RefSeq; XP_004180990.1; XM_004180942.1.
DR AlphaFoldDB; I2H519; -.
DR STRING; 1071380.I2H519; -.
DR GeneID; 14496544; -.
DR KEGG; tbl:TBLA_0E04160; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_1_2_1; -.
DR InParanoid; I2H519; -.
DR OMA; RKWISID; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000002866; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF3; DNA REPAIR PROTEIN RAD4; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT DOMAIN 448..513
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 515..569
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 578..661
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 26..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 963 AA; 112319 MW; 9468CC102A9B4793 CRC64;
MSDNLKPEYF QLLRKVLHEK ELENKKRQIE RRKKLQEEQS QNNNKRDVEE IIIPDDLDVK
PYVTKKKLKK YGSKYDNESI VEDPKMVINI DDDDNDDGNI SDFDEDEDFN SDEFEDVDVS
NNLTDLDGSI SITIDGSTSN KTKTASTRKN VCSNEVRSFR KYYHCIYLIS QIYSGTIYNE
YLNSTSLLKK LSLLVPDKTF DLLTPELDKE MPLRSTRKLL NGLKDCIKIW NKNWRLTSSN
TNSYFLMKTW EELQECDKNI PTSINRFNIK KAISKRKGDI HQSAMGFIAM LRSCNLNARL
IVSFQPPDFT NLKIIEKRKI NNISTFEYKY PFVWCEVWDK FSKNWITIDP IINKKIEQIQ
NFSLLEPKGL DSVDRNLIRY VIAFDRKNGV KDVTRRYTHW YNSKILKKRI TRTPKGEIWY
NKIISRFNRR KRIKIDDYED LYMKKRDLNE PMPDNLSDLK NHPFYVLENG LTKYQTLKKG
VVECGFLNIS KSSTASKKIG KKILKVYKRS DILELKSPKR WYMEGRVLKT GAKPLKTIIR
KNPYSLDNND ESEEERLYSF NETELYIPPI INPTTLEIPK NHYGNIEIFQ PTMIPNDCVL
IESPIAIKSA RFLDIPFAPA VTSFKFEKSK AGRRSNTRST KANLSGVVVS NKFKNALLTT
IDCMEYDIEN SRKIEETLSC LQNWNTLFLK LNIKNKLNYT YGTVQENSSK DNESNIQTFN
TDMDEIESED EDKDFASGGF LPRLSRNEGE APNDNNNQLL QLQSSDEMPE SMGGFLPQSN
IDIDTNMEQS VSDFDGGFLP IILDNNEVKN TINNEEVINS SNSHNAWIIP NNIEVGDISE
PVEPYEPISK RKTRLSSRMV KNKITDRKND SDSEHQEKFL VREQDIENNT IDDSDSYTQY
HVPANNINRQ IKPQKLSEPI SRRITRRHKN KINYYENVSV NDEIEDNPDM DDEYADFMNE
LNE
//
