ID I2H527_TETBL Unreviewed; 700 AA.
AC I2H527;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Checkpoint protein RAD24 {ECO:0008006|Google:ProtNLM};
GN Name=TBLA0E04250 {ECO:0000313|EMBL:CCH61479.1};
GN ORFNames=TBLA_0E04250 {ECO:0000313|EMBL:CCH61479.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH61479.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH61479.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad17/RAD24 family.
CC {ECO:0000256|ARBA:ARBA00006168}.
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DR EMBL; HE806320; CCH61479.1; -; Genomic_DNA.
DR RefSeq; XP_004180998.1; XM_004180950.1.
DR AlphaFoldDB; I2H527; -.
DR STRING; 1071380.I2H527; -.
DR GeneID; 14496552; -.
DR KEGG; tbl:TBLA_0E04250; -.
DR eggNOG; KOG1970; Eukaryota.
DR HOGENOM; CLU_027373_0_0_1; -.
DR InParanoid; I2H527; -.
DR OMA; ICLTECE; -.
DR OrthoDB; 2881303at2759; -.
DR Proteomes; UP000002866; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004582; Checkpoint_prot_Rad17_Rad24.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12172; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR PANTHER; PTHR12172:SF0; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR Pfam; PF03215; Rad17; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT REGION 628..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..660
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 80260 MW; DD0B738A6184E993 CRC64;
MGIKNQEFSS LSNPPVIQRN LSSLSSHINK WNTSRPTSPL KKEVKLTRKI SKPKARRISI
NDEQASCSNN NSPFNERNEN DMWFNIFKPS TLEDVCIHKK KANDIITALK GIMSGKEDIR
ILLLTGPSGC SKSTFIKEAS KILIPQYRAH GITSLFSEES GEHLPSTYIE YSNDAVLNGI
SSIDSFYEFL KESKYRVGSN LSIILVEDFP NLFHITTRQN FQKVILEWLY SSELILPPLV
ICLTECEIED TENNFRHSFG IETSWTAPTV LGNEILNHPK LKQIKCNPIN MTLTKKQLNF
LCNENKTLIM ANNKWQQKDI IIKDISQSTG DIRSGIAALQ FWATSSSDLP IITRKSPVSF
FHAVGRIIHG SKNLTDDNEM INELDAESET LISSSTFKLG LLENYPHFNK SDFSIKTAYD
VLDALSVGDC IKDDDKESLN YTLRKIRYSM NKQKINSNQH GKTSFPKEWK IRQLQNEMAV
ESSDLLNVSF FKYGQVRQTS DIYLDYAYYS PYICKLRQYK KKSLEYYLNT LPNNSPIRLE
TMRKNKDNLI VDDSIDIVER LGKEIKPLHL DSAEIEIDNS DINLKQQRPI DILRRKRDTK
LQALRSMYEK NYSQEYEEII PEEESYFEND PIVDPDDSSS NEDGLDNGFP ESDDEDDDAL
YEYLSQRKPQ NSQSQQQSIP TPSNNISFNE SLSDSDLEGL
//
