ID I2H596_TETBL Unreviewed; 644 AA.
AC I2H596;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=SET domain-containing protein 5 {ECO:0000256|ARBA:ARBA00042380};
GN Name=TBLA0E04990 {ECO:0000313|EMBL:CCH61548.1};
GN ORFNames=TBLA_0E04990 {ECO:0000313|EMBL:CCH61548.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH61548.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH61548.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR EMBL; HE806320; CCH61548.1; -; Genomic_DNA.
DR RefSeq; XP_004181067.1; XM_004181019.1.
DR AlphaFoldDB; I2H596; -.
DR STRING; 1071380.I2H596; -.
DR GeneID; 14496621; -.
DR KEGG; tbl:TBLA_0E04990; -.
DR eggNOG; KOG2084; Eukaryota.
DR HOGENOM; CLU_031650_0_0_1; -.
DR InParanoid; I2H596; -.
DR OMA; CEPNVRY; -.
DR OrthoDB; 56553at2759; -.
DR Proteomes; UP000002866; Chromosome 5.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd20071; SET_SMYD; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46402:SF2; HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5; 1.
DR PANTHER; PTHR46402; SET AND MYND DOMAIN-CONTAINING PROTEIN 5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 158..473
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 573..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 73301 MW; DF6101D8001B37AE CRC64;
MTKTISAGCC DDKSSNRSRS RSNNSSSNDS SSTHKLEHII LPSSVKELQK DATNIDCDEN
NDSNISASII PTNQEICDAV LLLWHEEPIQ EEKSLTEIRK RIQLKHPNWN INNIKDFEKI
LQLNNIYSID ENNLFTYDKL TTFNGIDSQL IDSEFPCDLL EVMIDPTCLN KGRGLYLKKN
LKRGEIIAKD IVPIVQIPPL EKLYLIDLGK VCSLCGTSIK HSKQFIMTHN LDCNNCQSIW
CSKYCLKNDK THSYLNHLKS KIKKDKIDLK NWKIYLNFIK KNNFQPGFVI ALIYTSILIE
ILVEKNSNDL NDSVIFKKFN SLATVSQKIR YDHCGSTNIG GSLDKYNRLF DTTTVLSTTT
NLNSNIRNNK HDQKKENKID DFNELWETAY DLFTKTFPSC VNDHNLTYEK YLNLIGRFNI
NQINGQLYPI ASLINHNCQP NIHIEVSDSN SLSLTLITRR NINIDEELLT TYINPLHGVK
LRRRELLVNW GFLCHCERCE KELKSRRLLT SEIIKNNDNG STSTNSAGEL SMINTSESST
IPTPTLSSLS NSSTSCIITP SITVNSYNKP IDTPASSSLS NSNVFNPNID SKRRKSSMRA
SRPDINELLK NGEEFDLDIP ESIGFKNRRT SVRFNNDVTL AVDE
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