ID I2H6M9_TETBL Unreviewed; 1561 AA.
AC I2H6M9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN Name=TBLA0G00840 {ECO:0000313|EMBL:CCH62031.1};
GN ORFNames=TBLA_0G00840 {ECO:0000313|EMBL:CCH62031.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH62031.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH62031.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
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DR EMBL; HE806322; CCH62031.1; -; Genomic_DNA.
DR RefSeq; XP_004181550.1; XM_004181502.1.
DR STRING; 1071380.I2H6M9; -.
DR GeneID; 14497163; -.
DR KEGG; tbl:TBLA_0G00840; -.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_001040_1_0_1; -.
DR InParanoid; I2H6M9; -.
DR OMA; DNHGDVT; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000002866; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0120015; F:sterol transfer activity; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProt.
DR GO; GO:0006887; P:exocytosis; IEA:UniProt.
DR GO; GO:0030011; P:maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IEA:UniProt.
DR CDD; cd13292; PH_Osh1p_Osh2p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF205; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT REPEAT 146..168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 246..278
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 330..428
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 923..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1486..1516
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 456..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1561 AA; 174164 MW; 04456AA9647D4968 CRC64;
MNGFNATANT FADANVVTQP VVNTNSAAIV STTPTGVPPV NPSPAHSSTP TTVSKPLLKL
KVLDTLRQGT IDDLQELLNT SFVPRDDPIV REVSQLLLHY AVQVAPLELI KEIVKKWVPT
STKSPKHNNS GENFVPHLDL NYQDGDGNTP LHLASEQSRG DVITYLMDLP NINDCILNDS
ELLPLEMCKN LNVAQMMQIK RANYVAATAK ELRNCLNSRD FKRLTKIFDN PRNKELLDIN
GIDPETGDTV LHEFIKKRDV HMCKWLIEHG SDPFKRDRSG KLPSDLLMNV NENDVPTNSK
MSIDVQLKKM LEKAAKEQSV INVANNLNEA PTLKGYLKKW TNFAQGYKLR WFVLSNDGRL
AYYKDQADTK NPNRGYLNMG TCYLHLDSTE KLKFEIVGGA TGTVRWHLKG NHPIETNRWV
WAIQGAIRFA KDKELLKGKN TVSPALVMNN YVSRENSTKQ VTATSNDGRS RSKTASSLSK
SDDSKGRTSS HKRSGSSNKS KVILPDDIRM SNNLTASGKS YVNRVLETRL ESSSPGTSIK
GVSLENTATT TKQKQSRSPS KSQQATNIPE STQYTAEPEA QQVQESMVDD TAMPVSTDTT
TEPPIQPQTL VQEPPLQTQQ AELQDLQEAA DSNYDYEPTD DAAYTGNYEQ QYSEGEALSD
EDEDDGIGMN IDTDDEDIQI QYGPFTQQVE LQQKHISMEL SSLTELLDTN IMDEASWSTI
KNSIKTITQC FEQLNTLSAS RDKKLVAMLT KQKDVNNVWI QSVKDLEREL GKKSQRLEAM
DKERRTLKKV VNKRIQDTES PQNVAKRLSK HDDSSSTLEQ VQKFISATKE NDEDSDVEEF
FDAEDASEDS DSVSSNIQSY DYSTVNGNTN SLSTTNPVLV TPMETPQLPA DIQPAQSTHA
TPAPVPVQPT QAAQVLAAQA QAHVQAQQQA QAFAQQQAQL QAQQQAQQQA QLQAQQQAQL
QAQQQAQAQA LAQQQAQAQA LAQQQAQAQA LAQQQAQAQA LAQQQAQAQA LAQQQAQAQA
LAQQQAEAEA QAQAHQEAQA QAQAQIQAQA QAQAQAQAQA QAQAQAQAQA QAQAQAQAQA
QAQAQAKAIQ AGPQPAKKSP EEMAEIVKVK TKEAEVIKKK APVKMMKTDL IAVTKSQAAR
EETLNAQGTW LGYEDGQRKR LALSEDDRPS ISLWSVLKSM VGKDMTKMTL PVTFNEPTSL
LQRVAEDLEY SELLDRACTF NDSTLRLLYV ACFAASSSAS TTQRVAKPFN PLLGETYEYA
RPDKHYRFFT EQVSHHPPIS ATWTESPKWD FWGESYVDTK FNGRSFEVNH LGLWYVKMRP
DDPKAPEELY TWKKPNNTVI GILVGNPQVD NHGDVTITNH NTGDKCTLHF KARGWRSSGA
FEVRGEVFDK KGDKKWVMGG HWNESYFAKK VTNKNKGNIS LEKTKSAAGS TEGPANDGSK
FLIWKVNDRP DAPFHLTPFA ITLNAPQPHL VKWVAPTDTR LRPDQRAMED GEYDKAANEK
TRLEEKQRAV RKKREEGNID YKPKWFTKET HPVTKLSYWK FTGKYWNERK VHDWKRCDDI
F
//
