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Database: UniProt
Entry: I2HAA6_CAEEL
LinkDB: I2HAA6_CAEEL
Original site: I2HAA6_CAEEL 
ID   I2HAA6_CAEEL            Unreviewed;      5187 AA.
AC   I2HAA6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 2.
DT   23-MAY-2018, entry version 56.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCH63813.2};
GN   Name=unc-68 {ECO:0000313|EMBL:CCH63813.2,
GN   ECO:0000313|WormBase:K11C4.5c};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:CCH63813.2}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCH63813.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCH63813.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCH63813.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; CCH63813.2; -; Genomic_DNA.
DR   RefSeq; NP_001256077.1; NM_001269148.1.
DR   ProteinModelPortal; I2HAA6; -.
DR   EPD; I2HAA6; -.
DR   PeptideAtlas; I2HAA6; -.
DR   EnsemblMetazoa; K11C4.5c; K11C4.5c; WBGene00006801.
DR   WormBase; K11C4.5c; CE52246; WBGene00006801; unc-68.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I2HAA6; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00006801; -.
DR   ExpressionAtlas; I2HAA6; baseline and differential.
DR   GO; GO:0031674; C:I band; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IGI:WormBase.
DR   GO; GO:0033365; P:protein localization to organelle; IMP:WormBase.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:I2HAA6,
KW   ECO:0000213|PeptideAtlas:I2HAA6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4552   4575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4738   4755       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4801   4823       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4939   4961       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4981   5006       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5066   5085       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1006   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1477   1696       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4298   4333       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4336   4368       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4311   4322       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4346   4357       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     1026   1046       {ECO:0000256|SAM:Coils}.
FT   COILED     4585   4607       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5187 AA;  589102 MW;  974777686B88EFF3 CRC64;
     MADKEEQGGG EQDDVSFLRT GDIVCLSCVA SHNRDGVLGS ERVCLCTEGF GNRMCTLENV
     SDKDIPPDIA MCMLYIDNAL SMRALQEMMS ADSDHKSASG AGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQETNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMAYS KGYMVIASFH QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI
     PENWSEHPQH NMVIYEGGAA VTQARSLWRV ELIRMKWHGA LVGWEQVFRI KHITSGRYLG
     VLDNSVQLYH KEKADFDLTA FVMCQNKDPK KQMLDEKEEE GMGNATIRYG ETNAFIQHVK
     TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF MALEEESKSA RVIRKCSSVL
     NKFLKGIDAL QLEGNQSTDW TRVDLNEVLK LMEDLIEYFA QPNDEQDFEE KQNHLRALRS
     RQDLFQEEGV LNMILDTIDK FSQMEALPDF AGLIGEETHV KWEQISTYLY LLVAAMIKGN
     HYNCAQFASA QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
     KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV SSMMPNVMLG
     VVEGSALFRK WYFEAEVEHI ETMTKQTPYL RIGWANSVGF KPFPGSGDKM GCNGVGDDFY
     SYGFDGKSMY FGGKSRRVGH KLLEKGDVIG CSIDLTIPEI KFSVNGTYMS GSFKKFNIDG
     YFFPVMSLSA KVSCRFILGG NQGRLRYGPP TGFSAVVEAV NGELQITDCL SFGDLGKNIF
     SGPQTIFNNL EPFIPTPIDV SATQLNHHAT EMHQKYAENL HELWAMRKIE LGWSYGETRS
     ETSRKHPCLT KFEYLPETEK KYNILLALTT MKTIEALGYH LITEDPPCRL RAVRLGPNFQ
     QQNGYKPGPL DTHEIQLPAE LQPLTEALAR NTHNIWAKEK IKRGWTFGLS EHVDATQKRS
     PHLVPYEQVD ERIKQANRES AAENIRALQL FGIFLEPPAH EHDEVAEKEL RARKDNTRTY
     RAEATYAVCG GKWYFEFEIL TAGYMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG
     AETYGKEWKI GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
     SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKQLPRF EDISTLKSGS
     ILEVSRIPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIK LSLPVKCNDT FVKNKDKETI
     RRQLQEYKPR SQSVVSQIRA PGIPKEFDDN KEKKGFLRSM LGSKDSHESD DDRRSRTNSK
     QPSVDGDEPP AVRRSLLELP HDERQIAEDS MRDLNDRHSE KPKKGGLLSR LRDSSNTRKN
     FRDSDRRKEE KAAQLRQMKA NSRSFDAGSL DTSTLPTGQK DVLASSEMPL SGPGRQLTIK
     RSSIKKNKKG KKAEIALEKM EREKKGSIIP MDAQLDVLQE GDAHALVHHK DKVDEYYYGI
     RIFPGQDPSQ VWVGWVTTQY HYYNVNFDGS QGVRKCRFSE ADHHGTTVDS VQSQNCYMVN
     VSELLATTPD VANTKVSGTL IGCIIDTSIG ELSFQVGSTD TGIKFKLEPG AMLFPAAFVT
     PTATEILQFE LGRIKYTFPL SAAMFKSCEK SLVPFCPPRL TVEQIESVYW ARVPNETLRT
     TALKLSEVRG WSVLCNDPVR IMSVYIPEKD QSLDILEMIE MPDMLEFHRQ TLNLYCKLAS
     HGNHKVAHTL CQHIDEDQIM YAIKSHYLSG PMRQGFHDLL IGLHLMSHTA ARNSMAKEYV
     IPLVPQLQIK NVLDPDSESR YPQITGESVS MLSQMASEPV KKHVSREDEM KLLPPSVDFE
     ALKKHVMESL QSATHHAVMN CRDLIGGDNT NHFEPLFKLF DQLLVIGLIN DEELECLLRL
     IHPQAFDENY ETGTTQKGLT QLELAEPVKI QLVSILDHLC DIQLRYRIES LVAFTEGFVG
     ELQSDQCKRY MEIKQTDMPP AEAAKKTKEF RCPPKEQMFR LLMCKVKEER DPELMEEDAD
     VDQCPMAEGL QQQLRDFCEL LVGKIGNVKE GDSDDQLALI ESEEGSWVDS FARIVVKVPP
     PVLEEGMEMQ KKGTQNFREI IVTMLREWAQ ADFIESKSLI RNMFRLLLRQ YSGIREIRDA
     MSQTYVFHER NEKDVTDFLV YLIQIRELLT VQFEHTEEAI LKRGLWKLMN NRIFFQHPDL
     MRLLSVHENV MSIMMNILTA QQGTVEHEGD ELKEKAPIKD ASEMVVACSR FLCYFCRTSR
     QNQKAMFEHL SFLLDNATML LARPSLRGSV PLDVAYSSFM DNNELALALK EEELDKVAVY
     LSRCGLQPNS ELITKGYPDI GWDPVEGERY IDFLRFCVWI NGENVEENAN LVIRLLIRRP
     ECLGVALKGE GQGLFSAFKE AIALSEDIRL LENDSHPSLL SSGLLGENPT YPSKDAEGED
     YIDLGAATLD FYSSLVDLLA KCAPDPMAIQ AGKGDSLRAR AILRSLISLD DLGQILALRF
     TIPNLAAPSI EAVRRANAVQ ASHTQKAVMA HTFAMVASLA SEVSNTRRSQ TFTSGTNLAK
     RGLPCVEEVD TDDSKSSDYA SVHTSFSSGN ELFAPKAEKE KVDVLKLNEN KYPIIQRRRS
     SRFNPIDNTG PLPGLLPNHK GSVLLFLDRV YGIDQQDMLF HVLEQSFLPD LRAATMMDSP
     RALESDTALA LNRYLCNSVL PLLTNHSHFF ADAEHHSALL DATLHTVYRM NRLKSLTKNQ
     RDAVSDFLVA ITRELPPAMM IKLLKKVITD ILTMNDMNVL VPLRLITLHY ERCGKYYGSG
     NHYGVASEQE KRLSMLLFDA IFDTLGSRPY DPELFGKALP CMTAIGSAIS PDYTLTSGLE
     DVRNKRREEE GAWIPRTVDV SRCEINRDLE KMTELFAEHF HDSWASRKLE KGWVHGDLYS
     RANFTHPRLK PFALLKDFEK SFYKERCSEC LKALMAWNYS FEMMDRDAND RASAARTLSG
     TSISNFAPKP IDLSSMTLEK DMVNAAEKMA EHSHLIWAKK VMNDLNTKGG FMPIPLVPWD
     LLTDFERRKD RFRASEILKF LQYHGYHVNC PKDEQSQNDR LKSEGERTSV EKRFAYNLLE
     KLITYLEQAS LKMKSVKPSQ ELTRRNSFKK EGQDVKFFEK VVLPLMHAYF NAHKNYFLEG
     SSIVQTGTAS NKEKEMVANL FCRLAALLRI KNRAFGSVAK ITVKCLQGLT QALDLRTLVK
     VNSDIVRTSL LTFFNNCADD LYASVNELKD GGQYSLIRGQ ALKSWNSFEF ANQMIVPVLT
     TMFAHLARNH FGTDLLLDDI QAACYKILDS LYMVTGLSSS ISHRKSISGE SEKHRPGLGQ
     CLAAFASCFP VAFLEPEFNK SNKFSVLAKS QDQSVQVQEM LQNLSTHIPH LEKLLTDLET
     VANNNTMYSD VPNVYDVDLP LMCSYMAHWF SVGPDGKRDK EDQRASVVQT TSVSCDHINR
     IFNALLKMIR NHVGIENAPW LCRVNFFAVQ IIQNVTSDPV REFVLPIAER LRRMSEKAYK
     EEEHMRTHPD DADEGTVAED NARLVRDTYA FFPILMKYTD LHRAQWLKTP TWETDGVYEN
     VAVIFRIWSQ SQHFKREELN YVAQFEEDAA ATGGGDMKTG KAAIAERKKK RREGQIKKDK
     HAASIVIACL KRLLPVGLNV FGGRELDIVQ QSKEKFIQKE TEEKIREFIK GLLEIPVKTD
     PTDKNAWQLS LYRKIGKSQM RGKDEMSQDA VIEKIFNMGQ VSAILHTMTS RMEKEDIWKK
     VLTLQRKRMA ISLITASHLY KTELHRGINF FLPAFSRLWM EEEDAGQDQL IADICSGVEE
     EEGPRIEIIM EEGVPIVASS EDTKEKETNP DPLKQLIRCF QRAATSEETA ASAIHEDSLY
     IRFADVMAKS IHIEEEDGED GEEGEIDQAA KEEQSQALRG EQAVLASRGA AIMCLMYLSA
     SGGEPNEMVA QTLQLGIHLL SGGNVEIQKM LIEYLQLKKD VRFFTSMAGL MNKCSVLNLE
     MFERQIKAEG LGMGAELASG DNQNLNDADF TCSLFRFLQL TCEGHNLEFQ NYLRTQPGHT
     TSVNLINCTV DYLLRLQESV MDFYWHYSSK EVIDEGGKEY FLRAIQVCSQ VFNTLTESIQ
     GPCVGNQMTL ANSRLWDAIN GFFFLFAHMM EKLYKNSTQL ELLREFLNLQ KDMIVLMLSM
     LEGNVLNGSI GKQMVDALVE SQPSVEKILK FSDMFLKLKD LTTSQAFQDF DTNQDGWISP
     KEFQRAMESQ KMYTVEDITY LMMCTDVNND GKVDYMEFTE RFHNPARDIG FNLAVLLVNL
     KEHITNDPRL EKIIEKAQTL LEYFDPFLGR IEIMGSSKRV EKIYFEIQES WLEQWGKQQI
     RDSKNSFLFN VLQDDGGDQG KLEAFINFCE DTIFEMQHAA AISSGDSDTK MERAIKQRDY
     FLQQTSADHI SETFKSGYNY GISAASALSP QNISTTMRNV SSSVRQMSWT QLLYAVIILF
     IRAGLAIGWA GYLLLMTIFR FGYFLTTSSE EEEAARQEKE QAKMNNEHPS FNPPIIQEFH
     HSHVGVTAFG VGMNADHLNV NSLPDFVPPE RPETPETVLE EEKPLNQETS PPTSPTSPAS
     KAPSIYESIG APQMVQLQSE ADFQQGQYEP KIAESNSTKS RGSILNMLAR NFKTIEKITL
     YLAFFINVIL LFHRVDISHA ENAEAASEGD DDEDALESIF ITGMQFPYVE YEITGWMLAQ
     ILYWISVLHL STSFALLVSF YQLKIPLITF KREKEIARKL MFDGCWITEE DSEELGIVDT
     FMWYLDRIVV SAKSFPMMYW DKFVRRKTRS KFKDQVDEET LTSILGEEKM STDSSYDYRY
     SCWLWIGVIL TNGQFLYRVG YLLCSACGVF LSPFFYAFHL IDVVLSFPML KAILQSVTHN
     LQQLILTIMM TLVVVYLYTV IAFNFFRKFY VQEGEEGEEP DRKCHNMLTC FIYHFYAGVR
     AGGGIGDELE SPYGDDLEYP RMFYDISFFF FVIIILLAIM QGLIIDAFGE LRDQQESATE
     KLESSCFICD IGKETFDRMP RGFEIHTTKE HNFANYLFFL QHLVNKDETE YTGQETYVRE
     KYDNRDWDFF PVGECFVKQY EDQLLQS
//
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