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Database: UniProt
Entry: I2HAA7_CAEEL
LinkDB: I2HAA7_CAEEL
Original site: I2HAA7_CAEEL 
ID   I2HAA7_CAEEL            Unreviewed;      5071 AA.
AC   I2HAA7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 2.
DT   13-FEB-2019, entry version 61.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCH63814.2};
GN   Name=unc-68 {ECO:0000313|EMBL:CCH63814.2,
GN   ECO:0000313|WormBase:K11C4.5d};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:CCH63814.2}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5d};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCH63814.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCH63814.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCH63814.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; CCH63814.2; -; Genomic_DNA.
DR   ProteinModelPortal; I2HAA7; -.
DR   SMR; I2HAA7; -.
DR   PeptideAtlas; I2HAA7; -.
DR   WormBase; K11C4.5d; CE52336; WBGene00006801; unc-68.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   OrthoDB; 5161at2759; -.
DR   Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR   Reactome; R-CEL-5578775; Ion homeostasis.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00006801; Expressed in 5 organ(s), highest expression level in material anatomical entity.
DR   ExpressionAtlas; I2HAA7; baseline and differential.
DR   GO; GO:0034704; C:calcium channel complex; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0031674; C:I band; IDA:WormBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IGI:WormBase.
DR   GO; GO:0033365; P:protein localization to organelle; IMP:WormBase.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:I2HAA7,
KW   ECO:0000213|PeptideAtlas:I2HAA7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4436   4459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4622   4639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4685   4707       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4823   4845       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4865   4890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4950   4969       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1006   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1477   1696       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4182   4217       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4220   4252       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4195   4206       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4230   4241       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     1026   1046       {ECO:0000256|SAM:Coils}.
FT   COILED     4469   4491       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5071 AA;  576319 MW;  C7DEE560133A0E00 CRC64;
     MADKEEQGGG EQDDVSFLRT GDIVCLSCVA SHNRDGVLGS ERVCLCTEGF GNRMCTLENV
     SDKDIPPDIA MCMLYIDNAL SMRALQEMMS ADSDHKSASG AGGHKTLLYG HAVQLKHVQS
     EMYLACLSSC SSNDKLAFDV GVQETNEGEA CWWTIHPASK QRSEGEKVRV GDDVILVSVA
     TERYLHMAYS KGYMVIASFH QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI
     PENWSEHPQH NMVIYEGGAA VTQARSLWRV ELIRMKWHGA LVGWEQVFRI KHITSGRYLG
     VLDNSVQLYH KEKADFDLTA FVMCQNKDPK KQMLDEKEEE GMGNATIRYG ETNAFIQHVK
     TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF MALEEESKSA RVIRKCSSVL
     NKFLKGIDAL QLEGNQSTDW TRVDLNEVLK LMEDLIEYFA QPNDEQDFEE KQNHLRALRS
     RQDLFQEEGV LNMILDTIDK FSQMEALPDF AGLIGEETHV KWEQISTYLY LLVAAMIKGN
     HYNCAQFASA QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
     KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV SSMMPNVMLG
     VVEGSALFRK WYFEAEVEHI ETMTKQTPYL RIGWANSVGF KPFPGSGDKM GCNGVGDDFY
     SYGFDGKSMY FGGKSRRVGH KLLEKGDVIG CSIDLTIPEI KFSVNGTYMS GSFKKFNIDG
     YFFPVMSLSA KVSCRFILGG NQGRLRYGPP TGFSAVVEAV NGELQITDCL SFGDLGKNIF
     SGPQTIFNNL EPFIPTPIDV SATQLNHHAT EMHQKYAENL HELWAMRKIE LGWSYGETRS
     ETSRKHPCLT KFEYLPETEK KYNILLALTT MKTIEALGYH LITEDPPCRL RAVRLGPNFQ
     QQNGYKPGPL DTHEIQLPAE LQPLTEALAR NTHNIWAKEK IKRGWTFGLS EHVDATQKRS
     PHLVPYEQVD ERIKQANRES AAENIRALQL FGIFLEPPAH EHDEVAEKEL RARKDNTRTY
     RAEATYAVCG GKWYFEFEIL TAGYMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG
     AETYGKEWKI GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
     SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKQLPRF EDISTLKSGS
     ILEVSRIPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIK LSLPVKCNDT FVKNKDKETI
     RRQLQEYKPR SQSVVSQIRA PGIPKEFDDN KEKKGFLRSM LGSKDSHESD DDRRSRTNSK
     QPSVDGDEPP AVRRSLLELP HDERQIAEDS MRDLNDRHSE KPKKGGLLSR LRDSSNTRKN
     FRDSDRRKEE KAAQLRQMKA NSRSFDAGSL DTSTLPTGQK DVLASSEMPL SGPGRQLTIK
     RSSIKKNKKG KKAEIALEKM EREKKGSIIP MDAQLDVLQE GDAHALVHHK DKVDEYYYGI
     RIFPGQDPSQ VWVGWVTTQY HYYNVNFDGS QGVRKCRFSE ADHHGTTVDS VQSQNCYMVN
     VSELLATTPD VANTKVSGTL IGCIIDTSIG ELSFQVGSTD TGIKFKLEPG AMLFPAAFVT
     PTATEILQFE LGRIKYTFPL SAAMFKSCEK SLVPFCPPRL TVEQIESVYW ARVPNETLRT
     TALKLSEVRG WSVLCNDPVR IMSVYIPEKD QSLDILEMIE MPDMLEFHRQ TLNLYCKLAS
     HGNHKVAHTL CQHIDEDQIM YAIKSHYLSG PMRQGFHDLL IGLHLMSHTA ARNSMAKEYV
     IPLVPQLQIK NVLDPDSESR YPQITGESVS MLSQMASEPV KKHVSREDEM KLLPPSVDFE
     ALKKHVMESL QSATHHAVMN CRDLIGGDNT NHFEPLFKLF DQLLVIGLIN DEELECLLRL
     IHPQAFDENY ETGTTQKGLT QLELAEPVKI QLVSILDHLC DIQLRYRIES LVAFTEGFVG
     ELQSDQCKRY MEIKQTDMPP AEAAKKTKEF RCPPKEQMFR LLMCKVKEER DPELMEEDAD
     VDQCPMAEGL QQQLRDFCEL LVGKIGNVKE GDSDDQLALI ESEEGSWVDS FARIVVKVPP
     PVLEEGMEMQ KKGTQNFREI IVTMLREWAQ ADFIESKSLI RNMFRLLLRQ YSGIREIRDA
     MSQTYVFHER NEKDVTDFLV YLIQIRELLT VQFEHTEEAI LKRGLWKLMN NRIFFQHPDL
     MRLLSVHENV MSIMMNILTA QQGTVEHEGD ELKEKAPIKD ASEMVVACSR FLCYFCRTSR
     QNQKAMFEHL SFLLDNATML LARPSLRGSV PLDVAYSSFM DNNELALALK EEELDKVAVY
     LSRCGLQPNS ELITKGYPDI GWDPVEGERY IDFLRFCVWI NGENVEENAN LVIRLLIRRP
     ECLGVALKGE GQGLFSAFKE AIALSEDIRL LENDSHPSLL SSGLLGENPT YPSKDAEGED
     YIDLGAATLD FYSSLVDLLA KCAPDPMAIQ AGKGDSLRAR AILRSLISLD DLGQILALRF
     TIPNLAAPSI EDTGPLPGLL PNHKGSVLLF LDRVYGIDQQ DMLFHVLEQS FLPDLRAATM
     MDSPRALESD TALALNRYLC NSVLPLLTNH SHFFADAEHH SALLDATLHT VYRMNRLKSL
     TKNQRDAVSD FLVAITRELP PAMMIKLLKK VITDILTMND MNVLVPLRLI TLHYERCGKY
     YGSGNHYGVA SEQEKRLSML LFDAIFDTLG SRPYDPELFG KALPCMTAIG SAISPDYTLT
     SGLEDVRNKR REEEGAWIPR TVDVSRCEIN RDLEKMTELF AEHFHDSWAS RKLEKGWVHG
     DLYSRANFTH PRLKPFALLK DFEKSFYKER CSECLKALMA WNYSFEMMDR DANDRASAAR
     TLSGTSISNF APKPIDLSSM TLEKDMVNAA EKMAEHSHLI WAKKVMNDLN TKGGFMPIPL
     VPWDLLTDFE RRKDRFRASE ILKFLQYHGY HVNCPKDEQS QNDRLKSEGE RTSVEKRFAY
     NLLEKLITYL EQASLKMKSV KPSQELTRRN SFKKEGQDVK FFEKVVLPLM HAYFNAHKNY
     FLEGSSIVQT GTASNKEKEM VANLFCRLAA LLRIKNRAFG SVAKITVKCL QGLTQALDLR
     TLVKVNSDIV RTSLLTFFNN CADDLYASVN ELKDGGQYSL IRGQALKSWN SFEFANQMIV
     PVLTTMFAHL ARNHFGTDLL LDDIQAACYK ILDSLYMVTG LSSSISHRKS ISGESEKHRP
     GLGQCLAAFA SCFPVAFLEP EFNKSNKFSV LAKSQDQSVQ VQEMLQNLST HIPHLEKLLT
     DLETVANNNT MYSDVPNVYD VDLPLMCSYM AHWFSVGPDG KRDKEDQRAS VVQTTSVSCD
     HINRIFNALL KMIRNHVGIE NAPWLCRVNF FAVQIIQNVT SDPVREFVLP IAERLRRMSE
     KAYKEEEHMR THPDDADEGT VAEDNARLVR DTYAFFPILM KYTDLHRAQW LKTPTWETDG
     VYENVAVIFR IWSQSQHFKR EELNYVAQFE EDAAATGGGD MKTGKAAIAE RKKKRREGQI
     KKDKHAASIV IACLKRLLPV GLNVFGGREL DIVQQSKEKF IQKETEEKIR EFIKGLLEIP
     VKTDPTDKNA WQLSLYRKIG KSQMRGKDEM SQDAVIEKIF NMGQVSAILH TMTSRMEKED
     IWKKVLTLQR KRMAISLITA SHLYKTELHR GINFFLPAFS RLWMEEEDAG QDQLIADICS
     GVEEEEGPRI EIIMEEGVPI VASSEDTKEK ETNPDPLKQL IRCFQRAATS EETAASAIHE
     DSLYIRFADV MAKSIHIEEE DGEDGEEGEI DQAAKEEQSQ ALRGEQAVLA SRGAAIMCLM
     YLSASGGEPN EMVAQTLQLG IHLLSGGNVE IQKMLIEYLQ LKKDVRFFTS MAGLMNKCSV
     LNLEMFERQI KAEGLGMGAE LASGDNQNLN DADFTCSLFR FLQLTCEGHN LEFQNYLRTQ
     PGHTTSVNLI NCTVDYLLRL QESVMDFYWH YSSKEVIDEG GKEYFLRAIQ VCSQVFNTLT
     ESIQGPCVGN QMTLANSRLW DAINGFFFLF AHMMEKLYKN STQLELLREF LNLQKDMIVL
     MLSMLEGNVL NGSIGKQMVD ALVESQPSVE KILKFSDMFL KLKDLTTSQA FQDFDTNQDG
     WISPKEFQRA MESQKMYTVE DITYLMMCTD VNNDGKVDYM EFTERFHNPA RDIGFNLAVL
     LVNLKEHITN DPRLEKIIEK AQTLLEYFDP FLGRIEIMGS SKRVEKIYFE IQESWLEQWG
     KQQIRDSKNS FLFNVLQDDG GDQGKLEAFI NFCEDTIFEM QHAAAISSGD SDTKMERAIK
     QRDYFLQQTS ADHISETFKS GYNYGISAAS ALSPQNISTT MRNVSSSVRQ MSWTQLLYAV
     IILFIRAGLA IGWAGYLLLM TIFRFGYFLT TSSEEEEAAR QEKEQAKMNN EHPSFNPPII
     QEFHHSHVGV TAFGVGMNAD HLNVNSLPDF VPPERPETPE TVLEEEKPLN QETSPPTSPT
     SPASKAPSIY ESIGAPQMVQ LQSEADFQQG QYEPKIAESN STKSRGSILN MLARNFKTIE
     KITLYLAFFI NVILLFHRVD ISHAENAEAA SEGDDDEDAL ESIFITGMQF PYVEYEITGW
     MLAQILYWIS VLHLSTSFAL LVSFYQLKIP LITFKREKEI ARKLMFDGCW ITEEDSEELG
     IVDTFMWYLD RIVVSAKSFP MMYWDKFVRR KTRSKFKDQV DEETLTSILG EEKMSTDSSY
     DYRYSCWLWI GVILTNGQFL YRVGYLLCSA CGVFLSPFFY AFHLIDVVLS FPMLKAILQS
     VTHNLQQLIL TIMMTLVVVY LYTVIAFNFF RKFYVQEGEE GEEPDRKCHN MLTCFIYHFY
     AGVRAGGGIG DELESPYGDD LEYPRMFYDI SFFFFVIIIL LAIMQGLIID AFGELRDQQE
     SATEKLESSC FICDIGKETF DRMPRGFEIH TTKEHNFANY LFFLQHLVNK DETEYTGQET
     YVREKYDNRD WDFFPVGECF VKQYEDQLLQ S
//
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