ID I2JJ29_9GAMM Unreviewed; 538 AA.
AC I2JJ29;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=DOK_11102 {ECO:0000313|EMBL:EIF42981.1};
OS gamma proteobacterium BDW918.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Spongiibacteraceae.
OX NCBI_TaxID=1168065 {ECO:0000313|EMBL:EIF42981.1, ECO:0000313|Proteomes:UP000003473};
RN [1] {ECO:0000313|EMBL:EIF42981.1, ECO:0000313|Proteomes:UP000003473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BDW918 {ECO:0000313|EMBL:EIF42981.1,
RC ECO:0000313|Proteomes:UP000003473};
RX PubMed=22740675; DOI=10.1128/JB.00678-12;
RA Kim S.M., Cho S.J., Lee S.B.;
RT "Genome Sequence of the Unclassified Marine Gammaproteobacterium BDW918.";
RL J. Bacteriol. 194:3753-3754(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIF42981.1}.
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DR EMBL; AJMK01000042; EIF42981.1; -; Genomic_DNA.
DR AlphaFoldDB; I2JJ29; -.
DR REBASE; 51095; M.Umb918ORF11102P.
DR PATRIC; fig|1168065.3.peg.2327; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_018284_2_0_6; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000003473; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI M PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:EIF42981.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003473};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000313|EMBL:EIF42981.1}.
FT DOMAIN 7..122
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 132..441
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 538 AA; 59725 MW; 6AF12516BDCB9125 CRC64;
MTNNDIVQKL WNLCDVLKDD GINYSDYVTE LVLLLFIKMV HENTESGILK KHHIPEGCRW
TDLNSKSGLN LMDAYKRILL ALSSGKDANG EQIHDDQLIS AIYADAQTRL REPRHLEQLV
KALDQIDWYS AQQDGLGDLY EGLLQKNSTE TKSGAGQYFT PRALINSMVR CIQPQPGEVV
QDPAAGTAGF LIAADRYIKD HSDDLFDLDA KAQNFQRNKA FIGVELVPGT RRMALMNCLL
HGMEGDDEGV VHLGNSLGMV GATLAKADII LANPPFGSSK GGEASITRDD LTYKTSNKQL
AFLQHIYRNL KPGGRAAVVL PDNVLFEAGV GNEVRRDLMN KCNLHTILRL PTGIFYAQGV
KTNVLFFTKG HPKDKLQDEN CTANVWVYDL RTNMPSFGKR TPFTEEHLKP FEKVFGKKAD
GTSKRSEGEW SWNAKEADVV EGAEENDDLA KSRWRVFSRG WIRDTKGDSL DISWLKDKDS
VDAANLPEPE VLAAEAMSEL TEALREMDGL MRALGAGDEA DIQKQLLQDV LGVGSELA
//