ID I2N070_STRT9 Unreviewed; 986 AA.
AC I2N070;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=AfsR/SARP family transcriptional regulator {ECO:0000313|EMBL:QKM69255.1};
GN ORFNames=STSU_020885 {ECO:0000313|EMBL:QKM69255.1};
OS Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS 9993).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM69255.1, ECO:0000313|Proteomes:UP000005940};
RN [1] {ECO:0000313|EMBL:QKM69255.1, ECO:0000313|Proteomes:UP000005940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC {ECO:0000313|Proteomes:UP000005940};
RX PubMed=22740677; DOI=10.1128/JB.00692-12;
RA Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT clinically important immunosuppressant tacrolimus (FK506).";
RL J. Bacteriol. 194:3756-3757(2012).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; CP029159; QKM69255.1; -; Genomic_DNA.
DR RefSeq; WP_006348674.1; NZ_CP029159.1.
DR AlphaFoldDB; I2N070; -.
DR Proteomes; UP000005940; Chromosome.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 4.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 21..117
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 105947 MW; 140F6E83AF17A83E CRC64;
MDRDSGPRVP EQRTPAPNEA SGANDAVDLR FSVLGPVRAW RAGQPLPPGS PQQRALLAAL
LLRDGRTATS HELIDAIWGE EPPSQALAAI RTYAHRLRKV LSASTLVSES GGYALRIERD
ALDLSVAQEL AAAAEKVRAA GDPGQARMMI NKSLGLWDGE PLANVPGPYA ENQRTRLDEW
RLQLMETRLD LDLEVGAHAE AVSELTALTA AHPLRERMRE LLMLALYRSG RQAEALAVYA
DTRRLLLEEL GVDPNPELSQ LQERILRADA ALAAPVEHHP APTPLAQPAQ LPATVPDFTG
RAAFVRELSE QLATAEGSVM AVSALAGIGG VGKTTLAVHV AHEARPRFPD GQLYVDLQGT
STRAAEPEAV LGAFLRALGL PEAAVPDTLD ERSALYRSTL AGRRVLVLLD NARDAAQIRP
LLPGTAGCAA LVTSRVRMVD LAGAHLVDLD VMSPEEALQL FSRIVGFERV SAERQSSLDV
VAACGFLPLA IRIAASRLAA RRTWTVSVLA EKLADERRRL DELQAGDLAV KATFELGYGQ
LEPGQAHAFR MLGLADGPDM SLAAAAAVLG LPVQETEDLL EALVDTSLLE SAAPGRYRYH
DLVRLYARSC AERDDTSEEG EAALARLLDF YLATAARVYG IERPGDRLVD HVGPVNLEGV
VFADRRRAQD WLYAEANCLL ASARQAAGGR RLKLAADLLW AAQGLAESGA NSKLYELAAL
AVRDAARAAG ELRTEARARV STTNVHLIAG RYEDADDEAR IAAELARAVG DAAPQYWSDN
DRGIIAFNQG RYEAAEGFLC SASEGARLDG SFSSEASALC NLSRTQLALD RVPEAIDLAR
QGVAIYERIN HTLRLANARY ALGVALTQAG RHADALEQLA EALDLFEANR QRLWEGTAHF
RIAQVHLSAR RAARAAQHCE QALAIGCIGG DRIRGIVLIT LGRALSALGQ ADRARVCWVE
ARSLLEAAGA PEAEEARALL SPLSTL
//
