ID   I2N380_STRT9            Unreviewed;       977 AA.
AC   I2N380;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Lantibiotic dehydratase {ECO:0000313|EMBL:QKM68361.1};
GN   ORFNames=STSU_015430 {ECO:0000313|EMBL:QKM68361.1};
OS   Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS   9993).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM68361.1, ECO:0000313|Proteomes:UP000005940};
RN   [1] {ECO:0000313|EMBL:QKM68361.1, ECO:0000313|Proteomes:UP000005940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC   {ECO:0000313|Proteomes:UP000005940};
RX   PubMed=22740677; DOI=10.1128/JB.00692-12;
RA   Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA   Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA   Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA   Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT   "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT   clinically important immunosuppressant tacrolimus (FK506).";
RL   J. Bacteriol. 194:3756-3757(2012).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP029159; QKM68361.1; -; Genomic_DNA.
DR   RefSeq; WP_006347620.1; NZ_CP029159.1.
DR   AlphaFoldDB; I2N380; -.
DR   Proteomes; UP000005940; Chromosome.
DR   InterPro; IPR006827; Lant_deHydtase_N.
DR   InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR   NCBIfam; TIGR03891; thiopep_ocin; 1.
DR   Pfam; PF14028; Lant_dehydr_C; 1.
DR   Pfam; PF04738; Lant_dehydr_N; 1.
PE   4: Predicted;
FT   DOMAIN          10..646
FT                   /note="Lantibiotic dehydratase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04738"
FT   DOMAIN          715..963
FT                   /note="Thiopeptide-type bacteriocin biosynthesis"
FT                   /evidence="ECO:0000259|Pfam:PF14028"
SQ   SEQUENCE   977 AA;  106881 MW;  453D4E20FCDCD5D6 CRC64;
     MWLRAVWANE DLVETLQHSS PALATQVQSL CTGQRPDPRD LRRAVLSVIR YLLRAQHRAT
     PFGLFAGVTT ATFRPRASAS WGEEHVLVGR AGADWLATVV QRLESCPELL ERLPVVANST
     ASVRGDRLIV PFQSDDRGDE TRAVEASLAL TAPVQAALTT AEAPIRVGVL LSKLRAEFPE
     AGPEKTRRLL AELIRRRVLI TSLWAPSTGT DALGHIVDQL DAVGAESIAP ISKTVAELVA
     IRAALEGCTT RGDRDGAAAR MRKLVPDGNG HPIAFDLRLK ARLVLPEAVA REVERAALIL
     TRLSTRPYGT ASWGEYHQRF YERYGIGTMV PLKEVVADSG IGYPDGYPGT PAGARRPQVS
     ARDDVLVRLA QTAALEGQEE VVLTDELIGA LDVGPDDPRV PPHLEVGVRV HSAGLDDLRR
     GRFRLEVVSV SRGAGVSTGR FLGVLEPGDR EALSTELADL PTEDSDTVPA QLSFPPLLPE
     SAHVTRAPQV LPTVISLQEH RAPDPDMLTL DDLAVACDGR RMYLAAPERG HRVEAVGMNA
     LNLRTHTPPL ARFLTELSRA QCAQVTVFDW GVAAAMPFLP RLRYGRTVLA PARWRLESSE
     LASGAKWDAA LADWRVRRRL PRQVYLVEGD QHLFLDLDEA GHRTLLREHL DRAHTALLVE
     APEGYGWCGG RAHEVVLPLK AVRLTAWPPL PAPTPARALS PAQMQPPATS SVLLATLYGD
     ARRQDTVLAQ HLPGLLERLG SPRWWFIRFR DPTQHLRLRI ALPHPDAFGE TARAVSGWAD
     ELRRAGLLAD LRYPTSYREM GRWGSGAAWE AAEDVFRADS RAVVTQLTQR QRPGQRVLVV
     AHTVAIASAF LGSTEAGMRW LLDHIPPTAP VPVPRPQFTE AVRLADPRRD WAALRGAPGG
     EAIVSGWADR DAALAAYRTH LPGRDTQGIA VDDVLTSLLH VHFVRHVAVN FPEEEVCLYL
     ARAAALAWIA RTKGRPS
//