ID   I2N547_STRT9            Unreviewed;       412 AA.
AC   I2N547;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Glycosyltransferase family 2 protein {ECO:0000313|EMBL:QKM67825.1};
GN   ORFNames=STSU_012245 {ECO:0000313|EMBL:QKM67825.1};
OS   Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS   9993).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM67825.1, ECO:0000313|Proteomes:UP000005940};
RN   [1] {ECO:0000313|EMBL:QKM67825.1, ECO:0000313|Proteomes:UP000005940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC   {ECO:0000313|Proteomes:UP000005940};
RX   PubMed=22740677; DOI=10.1128/JB.00692-12;
RA   Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA   Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA   Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA   Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT   "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT   clinically important immunosuppressant tacrolimus (FK506).";
RL   J. Bacteriol. 194:3756-3757(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC       {ECO:0000256|ARBA:ARBA00006739}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP029159; QKM67825.1; -; Genomic_DNA.
DR   RefSeq; WP_006347001.1; NZ_CP029159.1.
DR   AlphaFoldDB; I2N547; -.
DR   Proteomes; UP000005940; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   CDD; cd06442; DPM1_like; 1.
DR   InterPro; IPR039528; DPM1-like.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR007267; GtrA_DPMS_TM.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43398:SF2; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR43398; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   Pfam; PF04138; GtrA; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:QKM67825.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          30..199
FT                   /note="Glycosyltransferase 2-like"
FT                   /evidence="ECO:0000259|Pfam:PF00535"
FT   DOMAIN          272..386
FT                   /note="GtrA/DPMS transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04138"
SQ   SEQUENCE   412 AA;  43616 MW;  85DEB3833F3A1EAF CRC64;
     MSTTGTGTGA GEDTEPGIGA ADIAEPGAVT VVVPTFNESA NVRELLHRLT ESVPGRLPCE
     VVFVDDSTDT TPEVIRSAAQ DCPFPVTVIH RESPDGGLGG AVVEGLRAAG SEWIVVMDAD
     LQHPPALVPE LIAAGEAAGA DLVVASRYLR GGSREGLAGG YRIAVSRTAT WLTKALFPRG
     LRGISDPMSG FFAIRRSAVT DAVAAGELRP LGYKILLELA VRLRPRAVAE VPFVFRERFA
     GESKSTPAEG LRFLRHLVGL RTAAPLARMI AFGLIGLTGF VPNLLALYLL TQGGMHYLPA
     EVAANQFGVA WNFLLIEVLL FRDRRGHRHW ADRMGRFALL ANADLLLRIP LIALLVAGAG
     MPVLPATALA LLLTFVLRFA ATEALVYLPR GPRGSHGSGR PGASRPGSAD HV
//