ID   I2N5X6_STRT9            Unreviewed;       532 AA.
AC   I2N5X6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:QKM67566.1};
GN   ORFNames=STSU_010745 {ECO:0000313|EMBL:QKM67566.1};
OS   Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS   9993).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM67566.1, ECO:0000313|Proteomes:UP000005940};
RN   [1] {ECO:0000313|EMBL:QKM67566.1, ECO:0000313|Proteomes:UP000005940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC   {ECO:0000313|Proteomes:UP000005940};
RX   PubMed=22740677; DOI=10.1128/JB.00692-12;
RA   Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA   Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA   Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA   Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT   "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT   clinically important immunosuppressant tacrolimus (FK506).";
RL   J. Bacteriol. 194:3756-3757(2012).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; CP029159; QKM67566.1; -; Genomic_DNA.
DR   RefSeq; WP_006346702.1; NZ_CP029159.1.
DR   AlphaFoldDB; I2N5X6; -.
DR   Proteomes; UP000005940; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   NCBIfam; TIGR00831; a_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU366002};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM        82..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        111..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        221..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        266..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        299..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        344..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        377..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   DOMAIN          8..401
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   532 AA;  57249 MW;  BC39EAE3980C8C14 CRC64;
     MEALSLVALI AVSAAVAGAA RRTRVPAPLL LVAAGLVASY LPGVPDYTLD PHIVLPLVLP
     PLLHTAALDS SYLDLRANIR PVALLSFGYT LFATVAVGWL AYLLIPQLPL TAALVLGAVV
     APPDAVAATA IARRLGLPHR ITTILQGESL INDATAITAY RVAVAAAVGE GASWLGGMGE
     FAVAALGGVA VGLALMVPIH WLRTRLREPL LQNTLSLLIP FVAYAAAEQV HASGVLAVVV
     VALYLGHRSW QVDFATRLQE AAVWRMVAFV LESAVFALIG LQLSYVLRGL GDYGVAQALG
     YGVGVFVLVV AVRFVWVFPA TFLPRISPRI RAREPEVTWK APLVVGWAGM RGVVSLAIAF
     SIPLTTAAGE PFPSRNLVLF LTFTTVIGTL VVQGLTLPAL IRALRLPRPD PFAETLAEAE
     AQNAASEAAE RKLDALLADE RNALPEPLEE RLRTVMERRR NSVWERLGAV NEATGESADE
     TYRRLAREMI GAERAVFVQL RDARRIDDEM MRTLLFRLDL EEAAAYREED AD
//