ID I2N6K4_STRT9 Unreviewed; 683 AA.
AC I2N6K4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Protein-L-isoaspartate O-methyltransferase {ECO:0000256|ARBA:ARBA00013346};
DE EC=2.1.1.77 {ECO:0000256|ARBA:ARBA00011890};
DE AltName: Full=L-isoaspartyl protein carboxyl methyltransferase {ECO:0000256|ARBA:ARBA00031350};
DE AltName: Full=Protein L-isoaspartyl methyltransferase {ECO:0000256|ARBA:ARBA00030757};
DE AltName: Full=Protein-beta-aspartate methyltransferase {ECO:0000256|ARBA:ARBA00031323};
GN Name=fxlM {ECO:0000313|EMBL:QKM67390.1};
GN ORFNames=STSU_009655 {ECO:0000313|EMBL:QKM67390.1};
OS Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS 9993).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM67390.1, ECO:0000313|Proteomes:UP000005940};
RN [1] {ECO:0000313|EMBL:QKM67390.1, ECO:0000313|Proteomes:UP000005940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC {ECO:0000313|Proteomes:UP000005940};
RX PubMed=22740677; DOI=10.1128/JB.00692-12;
RA Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT clinically important immunosuppressant tacrolimus (FK506).";
RL J. Bacteriol. 194:3756-3757(2012).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. L-
CC isoaspartyl/D-aspartyl protein methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005369}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP029159; QKM67390.1; -; Genomic_DNA.
DR RefSeq; WP_006346482.1; NZ_CP029159.1.
DR AlphaFoldDB; I2N6K4; -.
DR Proteomes; UP000005940; Chromosome.
DR GO; GO:0004719; F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR027573; Methyltran_FxLD.
DR InterPro; IPR000682; PCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR023809; Thiopep_bacteriocin_synth_dom.
DR NCBIfam; TIGR04364; methyltran_FxLD; 1.
DR NCBIfam; TIGR03891; thiopep_ocin; 1.
DR PANTHER; PTHR11579; PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11579:SF0; PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE; 1.
DR Pfam; PF14028; Lant_dehydr_C; 1.
DR Pfam; PF01135; PCMT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01279; PCMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:QKM67390.1};
KW Transferase {ECO:0000313|EMBL:QKM67390.1}.
FT DOMAIN 42..243
FT /note="Thiopeptide-type bacteriocin biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF14028"
SQ SEQUENCE 683 AA; 73592 MW; 06A6FEA9DA592CE3 CRC64;
MDLNDENLPV TRETDWWHAT VALPGDAVSP EAALTLSAAL SGQRFHFLRK DGGLRLRTEH
PAAELLDRLA ADQIVSGWVP GVYEPETEAF GGPEAMDVAH DVFCADSRAA LAETGEPGGR
ERSVLLLSTM IRSAGLDPFE AGDVWAKLAA LRPPVTPPTG PALDTAVKAM RRLLNADAAR
RPNPEPDWAD RVAAFADGGL RLRRLAADGH LIRGLRAVLA HHAIFAFNRA GVPAAEQAAT
AWLGRHVAFS EGGAPDVSAH RAPHPGPTLA RMETTVTPDS SSATLREALA DRLVASGHLH
TPAVIDAFRT TDRHEFLPGV DLESAYKEDA VPIKHDEDGE MISCISAPSI VATQLEQLGA
RPGHTVLEAG AATGYNAGLL GKLVAPGGHV WTVDVDPDLV EGAQKNLAQA GASNVTAVLG
DGAAGLPEHA PFDRIQFTVG AGDVPVKLLD QLAPGGRLVL PMRIRGSISR SFAFERDGDS
WKTVSCEMAT FIPLRKGVCD DIYTRVRMEG EGTVHLETFS EQEVDRDAIR TVLDQKQSKV
YTGVKLRQGD PFEWMYLYLA FVLPNGLSRL PGQRPGFTPH FGWGSMAALD GDSLAYLTIR
EGEDEKGRYW EIGVIGHGSH AAELADHLAG EIRNWDEGWG NTAPEPTFRM AVGDARHQLT
ATDTRFVIDK TFSRLVVDWP RKG
//
