ID   I2NBI9_STRT9            Unreviewed;       871 AA.
AC   I2NBI9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Lantipeptide synthetase {ECO:0000313|EMBL:QKM65972.1};
GN   ORFNames=STSU_001155 {ECO:0000313|EMBL:QKM65972.1};
OS   Streptomyces tsukubensis (strain DSM 42081 / NBRC 108919 / NRRL 18488 /
OS   9993).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1114943 {ECO:0000313|EMBL:QKM65972.1, ECO:0000313|Proteomes:UP000005940};
RN   [1] {ECO:0000313|EMBL:QKM65972.1, ECO:0000313|Proteomes:UP000005940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 42081 / NBRC 108919 / NRRL 18488 / 9993
RC   {ECO:0000313|Proteomes:UP000005940};
RX   PubMed=22740677; DOI=10.1128/JB.00692-12;
RA   Barreiro C., Prieto C., Sola-Landa A., Solera E., Martinez-Castro M.,
RA   Perez-Redondo R., Garcia-Estrada C., Aparicio J.F.,
RA   Fernandez-Martinez L.T., Santos-Aberturas J., Salehi-Najafabadi Z.,
RA   Rodriguez-Garcia A., Tauch A., Martin J.F.;
RT   "Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the
RT   clinically important immunosuppressant tacrolimus (FK506).";
RL   J. Bacteriol. 194:3756-3757(2012).
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DR   EMBL; CP029159; QKM65972.1; -; Genomic_DNA.
DR   RefSeq; WP_006344751.1; NZ_CP029159.1.
DR   AlphaFoldDB; I2NBI9; -.
DR   Proteomes; UP000005940; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031179; P:peptide modification; IEA:InterPro.
DR   CDD; cd04791; LanC_SerThrkinase; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR007822; LANC-like.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   NCBIfam; NF038151; lanthi_synth_III; 1.
DR   Pfam; PF05147; LANC_like; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM01260; LANC_like; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF158745; LanC-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
SQ   SEQUENCE   871 AA;  93502 MW;  5C560ADF691413C3 CRC64;
     MNPEYGVYCQ TDGDFYDAPH RADGTATPDA SLFEPARDPA PEGWETHRSG DWLSFHPAGV
     ELPAQGWKIH VSAAADNAAS VLRRVHGHCL AHRIPHKFVP APRLLHLRNA KYADRAGSGK
     FITVYPPAED SFQEICEALT GLLDGEHGPY VLSDLRLGEG PVYVRYGAFA ARYCLGPDGR
     PVPAVANPEG TLVPDPRGPF LRIPGWVDPP AFLRPHLDAR EALGTTGTPY EIEAALHFSN
     GGGVYRARDS RTGETVVLKE ARPHAGLAAD GADAVARLES ERTALEQLAG FDCVPAVREA
     FDLGGHRFLA LEHIEGNTLN TLLARRYPLS APDPAPEALA EHAAWVERIH GLVEDAVRRI
     HARGLVFSDL HMNNIMVSED ESRVVLLDFE AAFPATDEDR RQIVANPAFV APADRTGTGI
     DRYALACLRI ALLAPLTTLF FIDRGLAPRM ARDTARLFGT GEAALVPAVR EIVRGRPGEH
     APEPAVPEPD DWPWSRDSMA RAIAASFTPE REDRCFPGDI TQFATPVGGQ CFGTGAAGVL
     HALHETGAPP CPEAVEWLLT RTKTVAPGTP PGFHDGLAGI AWTLNRLGHR DRAAELAHLV
     AEQPLDRLTP DLHSGQAGIA LAFDELARDA SGSDATAFAA AADRCAAYAA GSLTEGRPSP
     RTGLLHGATG LALLFVRRYE STGDPALLDL ARTALARDLD RCKPGKSGEL MVVEGKRLMP
     YLGAGSAGIA VVLDEYLAHR PDERFEAARE TIAPALRAAF YVQPGLYRGV AGLVLHLART
     PAGDPAERRS AVERHTRLLG LQATPYRGDL AFPGEQMMRR SMDLATGTAG VLLALGSAYG
     DTPAALPFLP PPPRPTDRPH PGVAHHQPSP R
//