ID I3D456_9ARCH Unreviewed; 771 AA.
AC I3D456;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=valine--tRNA ligase {ECO:0000256|ARBA:ARBA00013169};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
GN Name=valS {ECO:0000313|EMBL:EIJ66499.1};
GN ORFNames=BD31_I1245 {ECO:0000313|EMBL:EIJ66499.1};
OS Candidatus Nitrosopumilus salaria BD31.
OC Archaea; Nitrososphaerota; Nitrososphaeria; Nitrosopumilales;
OC Nitrosopumilaceae; Nitrosopumilus.
OX NCBI_TaxID=859350 {ECO:0000313|EMBL:EIJ66499.1, ECO:0000313|Proteomes:UP000003423};
RN [1] {ECO:0000313|EMBL:EIJ66499.1, ECO:0000313|Proteomes:UP000003423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BD31 {ECO:0000313|EMBL:EIJ66499.1,
RC ECO:0000313|Proteomes:UP000003423};
RX PubMed=22461555; DOI=10.1128/JB.00013-12;
RA Mosier A.C., Allen E.E., Kim M., Ferriera S., Francis C.A.;
RT "Genome sequence of "Candidatus Nitrosopumilus salaria" BD31, an ammonia-
RT oxidizing archaeon from the San Francisco Bay estuary.";
RL J. Bacteriol. 194:2121-2122(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-
CC tRNA(Val); Xref=Rhea:RHEA:10704, Rhea:RHEA-COMP:9672, Rhea:RHEA-
CC COMP:9708, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57762,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78537, ChEBI:CHEBI:456215; EC=6.1.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001624};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIJ66499.1}.
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DR EMBL; AEXL02000053; EIJ66499.1; -; Genomic_DNA.
DR RefSeq; WP_008297935.1; NZ_AEXL02000053.1.
DR AlphaFoldDB; I3D456; -.
DR PATRIC; fig|859350.6.peg.477; -.
DR OrthoDB; 23906at2157; -.
DR Proteomes; UP000003423; Unassembled WGS sequence.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF93; VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EIJ66499.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 18..559
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 607..752
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 771 AA; 89696 MW; 0D9409D7DD893104 CRC64;
MEPKISEKAW NPELEKNILK QWEEEKIYEF IPENENFTID TPPPYPSGRP WHIGAAAHYS
QIDMIARTAR MAGKNVYFPI GIDRNGLPVE LYTEKKHNIR MRETQRDEFL NLCREALDDL
EAEMILIMKN LGISGNFANY YRTDSEEYRS LTQATFIELW NRGEVYLANR PNNYDWVSGT
TIADAEITYE DIPTKLVYMK FKIQDTDKEI IIASTRPELL CACKTIIVNP EDERYTQYIG
KNIIVPITNA EVKLRTHHSA QQEFGSGAVM VCSYGDQNDV ALFREFEMEE IVAIGLDGKM
TEAAGEYAGL KPKQARTKII EDLESKGFVE KIEDIVHRTP VSERSKIPIE IIPMEEYYLK
QKDSVEKMKK LGQEIKFHPP MHKQILMNWL ESISIDWPIS RRRFYGTEIP IWYCKSCSEP
HVPEPGKYYK PWAEEAPFDK CTKCGKSEFV GEERTFDTWM DSSVSPLFVS KFNRDKEFFD
KVYPTTIRPQ AKDIVRTWLY YTLLRCEQLT GKKPWSEAWI MGYGLDEKGM KMSKSKGNAI
DPLPVIEKLG ADTFRFWSAS EINHGYDFRC NEQKIESTKK FLSKLWNVSR FLSSFPVIES
GNVNPTDKWI LAELDNLVKE CKKGYEEYNF FVPAIAIREF TWNLFAAHYI EMVKARAYGI
GFSDEERDGA IFTLHKTLST ILKLLAPITP FITEYLWKEL YSKESIHRQL QVEPESLEDQ
SSITKEITEF NSLVWNEKKK QNLSLKDTIS IEIPDNLKSY KNDLKSMHNL A
//
