ID I3DE20_HAEPH Unreviewed; 340 AA.
AC I3DE20;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA polymerase III subunit delta {ECO:0000256|ARBA:ARBA00017703};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holA {ECO:0000313|EMBL:EIJ69963.1};
GN ORFNames=HMPREF1050_0711 {ECO:0000313|EMBL:EIJ69963.1};
OS Haemophilus parahaemolyticus HK385.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=1095744 {ECO:0000313|EMBL:EIJ69963.1, ECO:0000313|Proteomes:UP000003016};
RN [1] {ECO:0000313|EMBL:EIJ69963.1, ECO:0000313|Proteomes:UP000003016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HK385 {ECO:0000313|EMBL:EIJ69963.1,
RC ECO:0000313|Proteomes:UP000003016};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase HolA subunit family.
CC {ECO:0000256|ARBA:ARBA00034754}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIJ69963.1}.
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DR EMBL; AJSW01000037; EIJ69963.1; -; Genomic_DNA.
DR RefSeq; WP_005706680.1; NZ_UGHI01000002.1.
DR AlphaFoldDB; I3DE20; -.
DR GeneID; 78223818; -.
DR PATRIC; fig|1095744.4.peg.1227; -.
DR OrthoDB; 9770982at2; -.
DR Proteomes; UP000003016; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd18138; HLD_clamp_pol_III_delta; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR032780; DNA_pol3_delt_C.
DR InterPro; IPR010372; DNA_pol3_delta_N.
DR InterPro; IPR005790; DNA_polIII_delta.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01128; holA; 1.
DR PANTHER; PTHR34388; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR34388:SF1; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR Pfam; PF14840; DNA_pol3_delt_C; 1.
DR Pfam; PF06144; DNA_pol3_delta; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EIJ69963.1};
KW Transferase {ECO:0000313|EMBL:EIJ69963.1}.
FT DOMAIN 21..189
FT /note="DNA polymerase III delta N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06144"
FT DOMAIN 213..336
FT /note="DNA polymerase III subunit delta C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14840"
SQ SEQUENCE 340 AA; 39432 MW; 316797DFD364DDC1 CRC64;
MLKLFPEALS QQLSKNLSPF YLLTGSDLLL LNESKDLIIH TARTQGFDEK TDITVGNDTK
WDEIFEMEQS MGLFFNRQII ILNLPENLTA AIAKHLDTLS QLAHSDLLLI FSLPKLSKAV
EKQAWFTKIE SQLVQVNCQT PEIGKLPNWL ATRAKIMDLQ IESEAAQLLC YSYEGNLLAF
KQILQQLQLR FTDGKITLNR VKEVVELSAQ FTPFQWIDAL LEGKTSRAVH ILQHLQNEEV
QPVVLLRIIQ KELFILLEIT RSPTPVLPNQ PLFTGNLRTE FDRLKIWQNR RAFYIQACQR
FTYAKLYRLI QDLAQLEKAV KQEFSDDVWM ELERFSFGFK
//
