ID I3DEW8_HAEPH Unreviewed; 225 AA.
AC I3DEW8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759,
GN ECO:0000313|EMBL:EIJ70261.1};
GN ORFNames=HMPREF1050_1232 {ECO:0000313|EMBL:EIJ70261.1};
OS Haemophilus parahaemolyticus HK385.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=1095744 {ECO:0000313|EMBL:EIJ70261.1, ECO:0000313|Proteomes:UP000003016};
RN [1] {ECO:0000313|EMBL:EIJ70261.1, ECO:0000313|Proteomes:UP000003016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HK385 {ECO:0000313|EMBL:EIJ70261.1,
RC ECO:0000313|Proteomes:UP000003016};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIJ70261.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJSW01000034; EIJ70261.1; -; Genomic_DNA.
DR RefSeq; WP_005706512.1; NZ_UGHI01000002.1.
DR AlphaFoldDB; I3DEW8; -.
DR GeneID; 78224040; -.
DR PATRIC; fig|1095744.4.peg.1096; -.
DR OrthoDB; 5634909at2; -.
DR Proteomes; UP000003016; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00759};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759}.
FT DOMAIN 55..153
FT /note="DNA mismatch repair MutH/Type II restriction enzyme
FT Sau3AI"
FT /evidence="ECO:0000259|SMART:SM00927"
SQ SEQUENCE 225 AA; 25400 MW; F379DB6C520EA94D CRC64;
MNLAKFPVSE AELLANAHWL AGFRLGEIAE MLNIPVPKDL KHDKGWVGQL IETALGAKAG
SKAEQDFAHL GIELKTLPIN EQGEPLETTF VSLAPLVQNN GITWQSSHVR HKLQKVLWMP
IEGSRQIPLA ERHIGQPILW QPSLEQERQL QRDWEELMEL IVLGQLHQIN ATLGEVLQLR
PKGRNSKALA NAVNEQGQPI QSLPLAFYLR KQFTRQILQK FLLTS
//
