ID I3EC15_BACMM Unreviewed; 335 AA.
AC I3EC15;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=DNA polymerase III subunit delta' {ECO:0000256|ARBA:ARBA00014363};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=holB {ECO:0000313|EMBL:AIE58558.1};
GN ORFNames=BMMGA3_00195 {ECO:0000313|EMBL:AIE58558.1};
OS Bacillus methanolicus (strain MGA3 / ATCC 53907).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=796606 {ECO:0000313|EMBL:AIE58558.1, ECO:0000313|Proteomes:UP000027602};
RN [1] {ECO:0000313|EMBL:AIE58558.1, ECO:0000313|Proteomes:UP000027602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGA3 / ATCC 53907 {ECO:0000313|Proteomes:UP000027602};
RX PubMed=25758049;
RA Irla M., Neshat A., Brautaset T., Ruckert C., Kalinowski J., Wendisch V.F.;
RT "Transcriptome analysis of thermophilic methylotrophic Bacillus
RT methanolicus MGA3 using RNA-sequencing provides detailed insights into its
RT previously uncharted transcriptional landscape.";
RL BMC Genomics 16:73-73(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP007739; AIE58558.1; -; Genomic_DNA.
DR RefSeq; WP_003347119.1; NZ_CP007739.1.
DR AlphaFoldDB; I3EC15; -.
DR STRING; 796606.BMMGA3_00195; -.
DR KEGG; bmet:BMMGA3_00195; -.
DR eggNOG; COG0470; Bacteria.
DR HOGENOM; CLU_006229_4_5_9; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000027602; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004622; DNA_pol_HolB.
DR InterPro; IPR015199; DNA_pol_III_delta_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00678; holB; 1.
DR PANTHER; PTHR11669:SF8; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF09115; DNApol3-delta_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:AIE58558.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000027602};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AIE58558.1}.
FT DOMAIN 245..329
FT /note="DNA polymerase III delta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09115"
SQ SEQUENCE 335 AA; 38404 MW; 405D8096F5A0F209 CRC64;
MAKTWTQLEE MQPSVLKMLK NSLIKDRLAH AYLFEGKRGT GKKEVGLLLA KSLFCQSPLE
GYIPCEACMN CRRINNGNHP DVHILEPDGL SIKKSQIQAL QEEFSKTGVE SKQKLYMIIH
ADRMTVNAAN SLLKFLEEPN SETTAILITE QIQQILPTIL SRCQTISFKP LSPQMMISRL
TANGVTPNLA PMLVQITNNL EEALELSHDD WFAQAQKIVL KLYEMLTKNP LEAMVHLQDQ
WFQHFKEKEQ LDRGLDLFLL IFKDLLYIQL GMHEKIVYLN EKARLEQFAL ETSGRRLTEQ
MTAILEAKRK LHANMNPQLL MEQLVLKLKE GSSFV
//
