ID I3EET1_NEMP3 Unreviewed; 660 AA.
AC I3EET1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Mechanosensitive ion channel MscS domain-containing protein {ECO:0000259|Pfam:PF00924};
GN ORFNames=NEQG_02275 {ECO:0000313|EMBL:EIJ87728.1};
OS Nematocida parisii (strain ERTm3) (Nematode killer fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=935791 {ECO:0000313|EMBL:EIJ87728.1, ECO:0000313|Proteomes:UP000002872};
RN [1] {ECO:0000313|EMBL:EIJ87728.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ERTm3 {ECO:0000313|EMBL:EIJ87728.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cuomo C., Troemel E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.,
RA Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Nematocida parisii strain ERTm3.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL870881; EIJ87728.1; -; Genomic_DNA.
DR AlphaFoldDB; I3EET1; -.
DR EnsemblFungi; EIJ87728; EIJ87728; NEQG_02275.
DR VEuPathDB; MicrosporidiaDB:NEQG_02275; -.
DR HOGENOM; CLU_030579_0_0_1; -.
DR InParanoid; I3EET1; -.
DR OMA; RIWDANY; -.
DR Proteomes; UP000002872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016688; MscS-like_plants/fungi.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR PANTHER; PTHR31618:SF7; MECHANOSENSITIVE ION CHANNEL PROTEIN; 1.
DR PANTHER; PTHR31618; MECHANOSENSITIVE ION CHANNEL PROTEIN 5; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002872};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 107..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 488..556
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 75516 MW; 7E68C38D54FC7AC1 CRC64;
MESNERENGN NSPSSTGDVS QKIKKLVTNP IQTRDTKASD DSEKSDDESN QEITHGDKII
EAVKEENKIK KQREKHKKRQ PMDDLEEEDK FSFFDTLGYI ERNLTGLWFY TAVFAYAVVG
CLLIMLSPTL VILLEKPGMP KLLMPITQYK GVTSSQINFK LGVFFCAVFL SYLVIYLIMN
RLVFIVAMVC DMFNHKISND GKIILFIVDD IKYLITVLIV SIFGIIHCNL FMEDYSLTRM
EVKGYGRLGG YSMCAGILFF FFIVEKFFLK LAIAYCGNNV FSGRIGDVNF KTSILRRLSI
YAQSINQRGM GNMNADSMEG IEITNTFLVH FVDFKIKSKS QCEDIVYEIL NSIAADDSNT
ENNDPNKPDA HLKMQITIDS IRDAFGNQWM EIWRYLESHE YVKEVDGNSV IRGKDLLNLA
ISVYGERIDL KRTLYDRDKI LGILDTILQI VAIILTLMIS TPFIGFNPIN ALAGFVPLLM
SSGWLFSDII KDVFNNFIFL LHEHAFDVGD KILVHSKEFT VLRIDLMYST FTSKGGTVCY
IPNKELIKES IFNVRRSDIQ TELVVFIIKD EVTIDKLNEI KEKIVNILKS KEQDSKKRIS
IQDYETKSDT TVITFRIEYL CNFRDPEPKF TRRHLPLEII QKALVSAGCS YAEQKAESTV
//
