ID I3EJY4_NEMP3 Unreviewed; 586 AA.
AC I3EJY4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|ARBA:ARBA00020444};
DE EC=1.1.1.49 {ECO:0000256|ARBA:ARBA00013019};
DE Flags: Fragment;
GN ORFNames=NEQG_00301 {ECO:0000313|EMBL:EIJ89531.1};
OS Nematocida parisii (strain ERTm3) (Nematode killer fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=935791 {ECO:0000313|EMBL:EIJ89531.1, ECO:0000313|Proteomes:UP000002872};
RN [1] {ECO:0000313|EMBL:EIJ89531.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ERTm3 {ECO:0000313|EMBL:EIJ89531.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cuomo C., Troemel E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.,
RA Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Nematocida parisii strain ERTm3.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-
CC phosphate pathway, which represents a route for the dissimilation of
CC carbohydrates besides glycolysis. The main function of this enzyme is
CC to provide reducing power (NADPH) and pentose phosphates for fatty acid
CC and nucleic acid synthesis. {ECO:0000256|ARBA:ARBA00025382}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:61548; EC=1.1.1.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000740};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 1/3. {ECO:0000256|ARBA:ARBA00004937}.
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DR EMBL; GL870876; EIJ89531.1; -; Genomic_DNA.
DR AlphaFoldDB; I3EJY4; -.
DR STRING; 935791.I3EJY4; -.
DR EnsemblFungi; EIJ89531; EIJ89531; NEQG_00301.
DR VEuPathDB; MicrosporidiaDB:NEQG_00301; -.
DR HOGENOM; CLU_032837_0_0_1; -.
DR InParanoid; I3EJY4; -.
DR OMA; NTSGACR; -.
DR UniPathway; UPA00115; UER00408.
DR Proteomes; UP000002872; Unassembled WGS sequence.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23429:SF0; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 2.
DR Pfam; PF00479; G6PD_N; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Reference proteome {ECO:0000313|Proteomes:UP000002872}.
FT DOMAIN 105..243
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 255..434
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 498..578
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EIJ89531.1"
SQ SEQUENCE 586 AA; 66855 MW; 987902881FA664A4 CRC64;
MIIIAGCTGD LSKKKLFPAI NKLFRRELYN CTNTNYTNKE LDLTDATLSS STSAHNLSKY
SPITHANPKD SKCNKNYLEA TESKILYKKI LQGDLLINNN IKIPRIIGYA RSILNSTQFI
QRIDPNISYL KETISNIEYY SGEYKDMVSN IYGMINEEYN MDSTVSNEPI YFYLAVPPEI
YPSILKSVKI LKNNGNNGIF KLPILLIEKP IGTSLNSFLQ LKQDILSDLD RSLCVDHYLF
KNVMVMYKDL YTTSVLQDII VPEHISEVKA YFNEVIGVSG RESYYNTSGA CRDVLQNHLL
LIISTVLAGT NSRLSILQDI TALTEGGTVF GVYKEYYKVI SRSISVCDSV RESYSETSLE
KISKIKNIPN KEIKNNGNIK NTDVKETFIR TVTKIGGNWN IPLKMTAGKK MPSHFVGVIL
IMKKSGILKF AKQKTDVKDY ENLKLLEKII KKLENPSKLD QDTQDISLSD DICVETDESV
NESEESTENF DKTKNTKKTT ISGKIKIKIT PKEEISVELK YKNKLAKKVN IPIPKTEDKI
DAYEHLFHQL IFKEDYSNFS ALSEIEEQWR IVDPILDSEN IRRVYY
//
