ID I3I9N0_9GAMM Unreviewed; 617 AA.
AC I3I9N0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=O59_002488 {ECO:0000313|EMBL:EIK44765.1};
OS Cellvibrio sp. BR.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Cellvibrio.
OX NCBI_TaxID=1134474 {ECO:0000313|EMBL:EIK44765.1, ECO:0000313|Proteomes:UP000003395};
RN [1] {ECO:0000313|EMBL:EIK44765.1, ECO:0000313|Proteomes:UP000003395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BR {ECO:0000313|EMBL:EIK44765.1,
RC ECO:0000313|Proteomes:UP000003395};
RA Peng Y.Y., Li N.Z., Xia T., Qiu R.R.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIK44765.1}.
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DR EMBL; AICM01000004; EIK44765.1; -; Genomic_DNA.
DR AlphaFoldDB; I3I9N0; -.
DR STRING; 1134474.O59_002488; -.
DR PATRIC; fig|1134474.3.peg.2333; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_007510_1_1_6; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000003395; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 299..374
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 473..560
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 617 AA; 69201 MW; E9160E90B72BEA1A CRC64;
MNTSNIKRYA PQARNNFIAA ITKQAAKYGI TESGIEPLEQ KGDLALIDGR PFPASIIKPR
AALVQKIKQL GFTQVIEQVA YSWFNRLCAI RYMELKDYLE HGRRVLSHPD QIGSFQILDD
CLDIDLAGLD QTKVRNLKLD GTQDELLYRE LLLAQCHALH KAMPFLFEAV DDETELLLPE
NLTKTDSLIH ELVNEIPEED WQSVEIIGWL YQFYISEKKD EVIGKVVKSE DIPAATQLFT
PNWIVKYMVQ NSLGAQWLAT YPESPLKAQM EYYITPAQQT DEVNAQLKAI TPSALNPEEL
TLIDPACGSG HILVEAYDLF KAIYLERGYR QRDIAQLILE KNLFGLDIDQ RAAQLTGFAL
MMKGRDDDRR LFEQDIKLNV MAMVDSTGFD VDALVGGVNL AQYGLEVNDL IELKNLFEHA
TTFGSLIQVP SGLKEKLPAL KQLSESNSDD LFVKESLENL QVLVKQAELL AQQYDSVVAN
PPYMGGKGMN TQLRDFAKNN YSNSKSDLFA MFIERNLDLA AGGGAVAMIT MQSWMFLSSY
ESLRSRILNQ HTILSMAHLG ARAFDSIGGE VVSTTAFVLG NVHKPDYQGA YMRLVDGNSE
AEKMEMMAKA IVQGRTV
//
