ID I3IRX1_DANRE Unreviewed; 771 AA.
AC I3IRX1; A0A8N7T5V6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Membrane-associated ring finger (C3HC4) 7 {ECO:0000313|Ensembl:ENSDARP00000125629};
DE SubName: Full=Protein FAM171B {ECO:0000313|RefSeq:XP_689740.2};
GN Name=fam171b {ECO:0000313|RefSeq:XP_689740.2,
GN ECO:0000313|ZFIN:ZDB-GENE-200618-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000125629};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000125629}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000125629};
RG Ensembl;
RL Submitted (MAY-2012) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000125629, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000125629};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|RefSeq:XP_689740.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_689740.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the FAM171 family.
CC {ECO:0000256|ARBA:ARBA00006818}.
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DR EMBL; AL929243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_689740.2; XM_684648.9.
DR STRING; 7955.ENSDARP00000125629; -.
DR PaxDb; 7955-ENSDARP00000125629; -.
DR Ensembl; ENSDART00000151195; ENSDARP00000125629; ENSDARG00000096271.
DR Ensembl; ENSDART00000151195.2; ENSDARP00000125629.1; ENSDARG00000096271.2.
DR GeneID; 561242; -.
DR AGR; ZFIN:ZDB-GENE-200618-1; -.
DR CTD; 165215; -.
DR ZFIN; ZDB-GENE-200618-1; fam171b.
DR eggNOG; ENOG502QRHY; Eukaryota.
DR HOGENOM; CLU_019729_0_1_1; -.
DR OMA; WIAAPHP; -.
DR OrthoDB; 4260817at2759; -.
DR TreeFam; TF331338; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000096271; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018890; FAM171.
DR InterPro; IPR049175; FAM171_C.
DR InterPro; IPR048530; FAM171_N.
DR PANTHER; PTHR31626:SF2; PROTEIN FAM171B; 1.
DR PANTHER; PTHR31626; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20771; FAM171A1-2-B_C; 1.
DR Pfam; PF10577; FAM171A1-2-B_N; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..771
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117875"
FT TRANSMEM 337..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..315
FT /note="FAM171 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10577"
FT DOMAIN 548..767
FT /note="FAM171 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20771"
FT REGION 39..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 84284 MW; F1A219A9AB857598 CRC64;
MSDLSGCLLL AALLIFSKDV SVRRAEGAAL TRGLASLSDQ DNAEDTRTSP VQGQGDATVS
PPSSESLLTL KVWVKDASSQ RFLTGALVSV FLNGSQIHSS RTLGNGEVTI IVPYRLGLTL
TLVASMEGYM LTQLPWKTTK IPIFSVITLS VHPQTQGNIW LFEDTVLIAR KTSDLSFQPS
VQFPKSLLKL PENTTISMLS AYLTAPGLPT EKDSNYFTLN LNGKGGYRNI KLSPLAMISA
QIVSNGKEVD VKGPIQLTIP LPYYTHLRPS DSLPAWTFNM TIGTWVNKGL GIVQMEKNGL
VWTYTAPQLG NWIAAPLPSS GYMGLASSMD FIYYHTYLLV GILGGTLVVV VGFLSVIVFH
CRDLNHEAGR RRWNSTRLTV LKKDQTTSTS SDEAQELFFH NGERSYSLAA RGISHDASDS
PRHQANYNIY VENVGRPGGN LYENIGAVGL EGLRAPMSNL YVNSDEVAKL REKMEQNGAR
HGGVENVVFK DKLFHIYNQP LAIVQAPELF NSQGQADPSG SRSATFPRNG MEHGAQTERN
LKDSFTQTLP KAPQQDNDEQ QSLEGAQAVA INPGLWGRYS HLLESVSVPG TLNEAAGMGP
FRGELQGISE QTLLELTKGK PSIHPPRAWF VSLDGKPAAQ VRHSVIELQG RHRPGSSNDT
SLDSGVDMNE LQQPLRKSEE PSSASMAKIS GNQEQDLSSS EIGSPEDSSL RNTLESSSAA
IPNLPEDRDA GDTSSESKST PPPRRLRKVR DKKPDKKTSR HMREERPQTK H
//
