ID I3IU38_ORENI Unreviewed; 1208 AA.
AC I3IU38;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=TBC1 domain family, member 9 (with GRAM domain) {ECO:0000313|Ensembl:ENSONIP00000000128.2};
GN Name=TBC1D9B {ECO:0000313|Ensembl:ENSONIP00000000128.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000128.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000128.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3IU38; -.
DR STRING; 8128.ENSONIP00000000128; -.
DR Ensembl; ENSONIT00000000127.2; ENSONIP00000000128.2; ENSONIG00000000105.2.
DR eggNOG; KOG4347; Eukaryota.
DR GeneTree; ENSGT00940000158554; -.
DR HOGENOM; CLU_003535_0_1_1; -.
DR InParanoid; I3IU38; -.
DR OMA; CTGEVPT; -.
DR TreeFam; TF313145; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd13351; PH-GRAM1_TCB1D9_TCB1D9B; 1.
DR CDD; cd13354; PH-GRAM2_TCB1D9_TCB1D9B; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR036014; TCB1D9/TCB1D9B_PH-GRAM1.
DR InterPro; IPR036017; TCB1D9/TCB1D9B_PH-GRAM2.
DR PANTHER; PTHR47666; PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47666:SF1; TBC1 DOMAIN FAMILY MEMBER 9B ISOFORM X1; 1.
DR Pfam; PF02893; GRAM; 2.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00568; GRAM; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 494..681
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 865..900
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 393..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 137103 MW; DE92A4589BBFDDBA CRC64;
MLSDMVQVQN TFNPNTDQIQ ITAQVASPVC LCAGLLVGTL DVVLDSSARV APYRILLQTA
DSQIYWNIAC GSSRKEITEH WDWLEANLLQ TISIFDNDED ITTFVKGKIS GIIAEENRLK
PGEEHEEDSG KFREAELKMR KLFGMPEEEK LVNYYSCSYW KGRVPRQGWL YLSVNHLCFY
SFLLGKEVTL VVPWTEVTQL EKNATLLFPE SVRVSTRDTE HFFSMFLNIN DTFKLMEQLA
NIAMRQLLDN EAFAADLSLP KPSKTLKNVS ALKRDLDARA KNERYRAMFR LTQEERLDGH
TDCTLWTPFA KMHVVGQLFI SNNYICFSSK EEDLCQLIIP LREVSIVEKA DSSSVLPCPV
SISTKNKMNF LFANLKDRDF LVQRISDFLQ RTPDSSWGDT NPLSQISHSA SSAVPPSSSP
GSESVQKGRH YHPGLPTAIQ GLLQLYHRDD PEDLGPKAMR EKMKEESWNI HFLEFGRGVC
MYRTSRTREL VLNGIPERLR GELWLLFSGA QNEMATHPGY YGELVEQAMG LCSLATEEIE
RDLHRSMPEH RAFQNEMGIA ALRRVLTAYA HRNPGIGYCQ AMNIVTSVLL LYCTEEEAFW
LLVALCERML PDYYNTRVVG ALVDQGVFEE LTRSFLPLLY EHMQELGVIS TISLSWFLTL
FLSVMPFDSA VLLVDCFFYE GIKVIFQVAL AVLHDNMDAL LSCSDEGEAM TILGRYLDNV
VNKQTVAPPI PHPHALLTSG DEPPPEIDVF DLIKSSYEKF GSLRSDVIEQ MRFKQRLKVI
QSLEDTAKRS VVRAMMTESA FSIEELEELY CLFKSKHMTS CYWGSSSSAA ERHDPSLPYL
EQYRIDPLQF RQLFVSLAPW VCGGHNPTLS ARLFRLLDQN QDGLVNFKEF ITGLSGMYHG
DMTEKLKLLY KLHLPPALCP EEAESALEAT QFFTEEEPRE ASFFSDQNAL RQQEVTPGEE
PKDGDSEEKK EVKDYRYYLR MWAKEKETKR ETIKDLPRMN QEQFIELCKT LYNMFSEEAL
EQQLYHAIAT VASLLLRIGE VGKKFNNGTK KRETMPQTSL SAQNPPHSPQ GEEEGPGHGA
SGESEVCRAL ADAQLEVVAP QMSDEETKDD VSVSSYSVVS AGSLQCEDIA EDTVLIRGSE
QRQGSVLDTD WSITFEQVLA SMLTEPPLVD YFERKRDIQA KMAACKAQRA VERQISSASD
HELTQHST
//