ID   I3IVH1_ORENI            Unreviewed;       370 AA.
AC   I3IVH1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Asporin {ECO:0000256|PIRNR:PIRNR002490};
GN   Name=aspn {ECO:0000313|Ensembl:ENSONIP00000000611.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000611.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000000611.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|PIRNR:PIRNR002490}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class I subfamily. {ECO:0000256|ARBA:ARBA00009811,
CC       ECO:0000256|PIRNR:PIRNR002490}.
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DR   AlphaFoldDB; I3IVH1; -.
DR   STRING; 8128.ENSONIP00000000611; -.
DR   Ensembl; ENSONIT00000000610.2; ENSONIP00000000611.1; ENSONIG00000000479.2.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000157444; -.
DR   HOGENOM; CLU_000288_186_0_1; -.
DR   InParanoid; I3IVH1; -.
DR   OMA; NRIQKDA; -.
DR   TreeFam; TF334562; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   InterPro; IPR016352; SLRP_I_decor/aspor/byglycan.
DR   PANTHER; PTHR45712; AGAP008170-PA; 1.
DR   PANTHER; PTHR45712:SF2; ASPORIN; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF01462; LRRNT; 1.
DR   PIRSF; PIRSF002490; SLRP_I; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR002490-1};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW   ECO:0000256|PIRNR:PIRNR002490};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..370
FT                   /note="Asporin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013062282"
FT   DOMAIN          64..96
FT                   /note="LRRNT"
FT                   /evidence="ECO:0000259|SMART:SM00013"
FT   REGION          39..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        65..71
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT   DISULFID        69..78
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
FT   DISULFID        323..356
FT                   /evidence="ECO:0000256|PIRSR:PIRSR002490-1"
SQ   SEQUENCE   370 AA;  42195 MW;  E91320796878E7E0 CRC64;
     MRIFLLLCLL ALGNAKPYQP INVMDYLKNY DTKIHEIMMS DSNDDDDDDE VDDDDDDDDY
     NDEDCPAHCH CSPRVVQCSD QGLISVPDKI PEDTVMIDLQ NNDITEIQQD DFKGLNKLYG
     LFLINNKISR IHPKAFKNMD NLRLLYLSYN MLNEIPANLP PNVIELRFHE NQIDRIQKDA
     FKGLRKLHVL ELGANPLTNS GIEIGAFNGL STLYIGIAEA KLTSIPKDFP SSITELSLDY
     NKISKVEIED FIRYKNLQRL GLAFNQIKYV ENGSLANTPK IREIYLDNNR MRKVPPGLSS
     LRYLQVIFLH GNKISSVGIN DFCPIRADSK KNPYTGISLF ANPVKYWAIQ PATFRCVTGR
     RGVQLGNFRK
//