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Database: UniProt
Entry: I3IVI7_ORENI
LinkDB: I3IVI7_ORENI
Original site: I3IVI7_ORENI 
ID   I3IVI7_ORENI            Unreviewed;       961 AA.
AC   I3IVI7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   05-JUN-2019, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000000627};
GN   Name=LOC100703495 {ECO:0000313|Ensembl:ENSONIP00000000627};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000627, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000000627}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AERX01001478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01001479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005474305.1; XM_005474248.3.
DR   STRING; 8128.ENSONIP00000000627; -.
DR   MEROPS; M12.212; -.
DR   Ensembl; ENSONIT00000000626; ENSONIP00000000627; ENSONIG00000000492.
DR   GeneID; 100703495; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   GeneTree; ENSGT00940000155495; -.
DR   OMA; NFHSHSL; -.
DR   OrthoDB; 162519at2759; -.
DR   TreeFam; TF314733; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    961       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003671507.
FT   TRANSMEM    722    744       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      228    430       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      438    524       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      670    702       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      766    799       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I3IVI7}.
FT   REGION      853    961       Disordered. {ECO:0000256|MobiDB-lite:
FT                                I3IVI7}.
FT   COMPBIAS    927    953       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                I3IVI7}.
FT   DISULFID    496    516       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    674    684       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    692    701       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   961 AA;  104746 MW;  3B9138018FE51F65 CRC64;
     MMRTWRRRKN FGFLILALRV WCLSTAAKHA DSMVYNIQRG SSPAEQSGEA TRPQTYETAI
     PLLLKGKERR PLSQLTSGRY PASLQLLVPA EGEQLILLLE KNEGLFASHY TETHYREDGS
     AVTGAHNFTS HCYYHGEVQA HPSSDVTLST CSGLRGFIAL ENKTFIIEPV SGDDTGVHFI
     YRVEELRLTP GACGHSFNTS SVASENHIES PFKSFHTRHK RHAQKTTKYV ELIIVADNRE
     FQKQGKDLEK VKQRLVEIAN YVDKFYRALN IRVALVGLEV WSDSDKCPIT QDPFTTLHEF
     LDWRKVKLLP QKPHDNAQLI SGVYFQGTTI GMAPIMSMCT AEQSGGIVMD HSDNPLGAAV
     TLAHELGHNF GMNHDTPERG CGCRMTVDRG GCIMTPSTGY PFPTVFSTCS KKDLAASLEK
     GVGMCLYNMP EVKVLYGGQK CGNGYVEEGE ECDCGEPEEC MNPCCNATTC TLKEDAVCAH
     GQCCEGCRLK PAGTLCRETS NSCDLPEFCT GASPHCPANV YLHDGHACHN VDGYCYNGIC
     QTHEQQCITL WGAGAKPAPG ICFERVNSAG DPYGNCGKDS KGSFAKCDAS DAKCGKIQCQ
     GGANRPVIGT NAVSIETNIP LQEGGRILCR GTHVYLGDDM PDPGLVLAGT KCGDNMVCLN
     RQCQNVSVFG VHECSGKCSG RGVCNNKKNC HCEAHWAPPF CETAGFGGSI DSGPMRAAAD
     TVLITVAILV TLVSLLVATV IIFLKRKTLL RFLFTNKKST LEKLRSVEAT RPTSPIRSES
     MYRPTPQRKP PPKPSGANIF KPSLLSAEPL LPPHNFHSHS LRRLPLYQPL HISQPMPVSL
     SVGQPTLPPL PAHYKVLPTH ASSSPPPRVQ PFLSLPRHQS SYRVDQDFEK PSPPQKPLPA
     DPLGRSSRLG HSAATAGGHI PGKAALPIPI PTVPRPPPSI PLPSRPAPAL PYRPPKTQKD
     C
//
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