ID I3IVQ6_ORENI Unreviewed; 1758 AA.
AC I3IVQ6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Fer-1-like protein 4 {ECO:0000313|Ensembl:ENSONIP00000000696.2};
GN Name=LOC100698227 {ECO:0000313|Ensembl:ENSONIP00000000696.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000696.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000696.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000068608; -.
DR Ensembl; ENSONIT00000000695.2; ENSONIP00000000696.2; ENSONIG00000000548.2.
DR eggNOG; KOG1326; Eukaryota.
DR GeneTree; ENSGT00940000160586; -.
DR HOGENOM; CLU_001183_3_1_1; -.
DR TreeFam; TF316871; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF36; FER-1-LIKE PROTEIN 4; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 5.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1727..1747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..169
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 211..349
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 748..880
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 921..1045
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1187..1307
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1435..1584
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 401..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1618..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1758 AA; 201296 MW; 88F446693E262E23 CRC64;
VSVYNCKLEI RFHPLEGTKN RFLKNLICSK DLFYESGHCK IPLSLHTIKT INLNCVCVCV
CVCVCVQVNV NILEAQKLVG VNINPAVFIS VGNQKRHTAT QKSTNCPFYN ENFQFDFQEA
PQTFLDKVIE IKVFHRRTLA FLLTHIGTFK IDISTVYNQP DHRFYQKWAP LTDPADTRSG
IKGYVKASLN VLMKGDTLSM PSLPPSSSSG ASEDIEKNLL LPRGMPSERP WARFRVRIYR
AEGLPTMEAG LMAFVSVTDR TVFIDPYVKV TFAGQQGETS VATATNCPVW NEEISFIEQF
PPLAQRIKVQ ILDDSKMGDI ALATHFLDLQ QISDPTRNGF NPTFGPSWVN LYGSPQNSTL
GDVHQALNEG LGEGLFYRGR ILLALSMEVY SSPSVKGALS KLGSRKKRSS KKDKKEGEVS
TDLRVSSYFP PQGLLGQKEE FLLFASLFEV TMMEPSVGTK PITFELSIGK CGGQFAGYGN
CCREELRSSR EDLSEETRNL LDSEDELDRE EVQSPEPENR SCLQLHPPLV KSKPCLFVWS
QFEDHSFRLY QANWLSKMAD RLEIGLDEVE KLLRRPRSKS KQRLDEVLLE LVVSCKQFSA
FSEKRSQSRP NNLDKCRRNF IKKNLILLAR QAVRARRRIT RRTAKQRLME SKRLLKKLRL
LAVEPQSTIP DAFIWLLSGN KRLAYVRIPA YSILFSLVEE QRGRDCGKVS TLYMKSPGGP
ASEIFAKLEV YLWLGLTKYS KEVISCLPED FLFGSCWFGS LSTDRRYYQL RCHLYQGRGL
MAADDDGLSD PFARVVFTTH CQVTRMLPDT LSPAWCECLV FDRVLLEGTR EDLQQDPPLI
IINIYDYDAG GPKPLGRAFA EPEFKTVEEL YEKPRLRFFD VNMGRVSAGE LLAAFELIEL
DYSGFGEPTL PSHVDPQELN YDEEYNFHLI PEGVRPVLKT FRIEVLFWGL RDLKRVHLFE
VEHPQVKIEC AGRQLESEEI QSYKTNPNFK EVVHYMDLPE ESYLHPPLTV FVVEHRAFGH
VALVGSHVVQ NLMDYGPREV AGEPEEEEEP KPKGKTCKIS LMLLSGAPLK KIRNKEEELE
EEVPEKEELD WWSKYYASLE ELEKQQSRFG AGEDFQTFFS VCCVFVCVQL YGGDLESEFS
QFQDWLRVFP VYKGRASGED DEEDEEARLM GKYKGSFLVY PIEPEDTEDT SCQIIKGIPK
NLPVKVLVRV YIVKATSLAP TDPNGKADPY LVIQVGEQNM DTKDRYIPKQ LNPIFGEVFE
LTVSFPLETE LVITVMDHDL VGADDRIGET RIDLENRFYS GHRASCGLAV YYDTDGYNMW
RDAKKPSTIL NELCRKYGIP SPEYRPSEVK VLNKIFKVPP DAIPEGKTER KRETEIQEHA
ALSLLHRWGE MNEFIAGVVP LVPEHVEIRS LMNQDNPGLP QGYLHMWVDM FPTDIPAPPP
IDIKPRLPEQ YELRVIIWNT DDVFLDDVNP FTGDPSSDIY VKGWIKGLEG DKQETDVHFN
SLTGEGNFNW RFVFRFDYLP TEKEVVYKKK ESIFSLEESE FRQPAVLTLQ VWDYDRIAAN
DFLGAIELRL SDMVRPAKSS GKCTISMAKD WASPRFSIFR AKKMKGWWPL TRPKTAEDFE
REEKEKEEAK KKGRKKKKKN KDKRSKMREE DIQYTDSMGN TFLLMGKVEA ELQLVTLEQA
EANPVGRARK EPEPLDKPNR PTTSFAWFVN PMKTFVFLIW KKYKKYIIAL VIITILTLFI
VLIVYTMPQQ ISSLIING
//
