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Database: UniProt
Entry: I3IW37_ORENI
LinkDB: I3IW37_ORENI
Original site: I3IW37_ORENI 
ID   I3IW37_ORENI            Unreviewed;      5000 AA.
AC   I3IW37;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   20-JUN-2018, entry version 42.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSONIP00000000827};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000827, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000000827}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AERX01001510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01001511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01001512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01001513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01001514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000000827; -.
DR   Ensembl; ENSONIT00000000826; ENSONIP00000000827; ENSONIG00000000653.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I3IW37; -.
DR   OMA; THEKWSL; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4302   4320       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4500   4521       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4570   4591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4706   4725       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4766   4788       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4847   4870       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    167       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    227       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      235    290       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    359       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      361    417       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      619    823       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1039   1237       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1352   1568       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4042   4077       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3338   3358       {ECO:0000256|SAM:Coils}.
FT   COILED     3716   3736       {ECO:0000256|SAM:Coils}.
FT   COILED     4670   4690       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5000 AA;  564775 MW;  C25DFBA1660CDB24 CRC64;
     MTDSGEGDDE FQFLRTGDEV VLQSTFTSQE EHVKLCLAAE GFGSRLCRLE PTSNCKNVPP
     DLSVCGFVLA QCLSVRALQE MLAHSEHLAA ELKLMFVYFN HIQVGAGGSH RTLLYGQAVL
     FLHSYSGMIQ YFSCLPSSQS STDKLAFDVG LQEDKAGEAC WWTVHPASRQ RSEGEKVRVG
     DDLILVNVSS ERYLHLSFGT ASDNKSLSDS LIVNAAFQQT LWSVAPICSG RAVAQGYLKG
     GETLRLLHSH SDACLTVPST EHGEELQRIM HYEIGSVSGH ARSLWRLEIL RVVWSGRHTC
     WGQPFRLCHV TTGRYLGLTE EKGLQLVDRD KADINTTSFC FRSSKEKLDT NTKTDVDGMG
     IPEIKYGDSI CFLQHVASGL WLTYQAADAK SHMGGAQRKA ILHSEGHMDD GLTLSRSQRE
     ESHIARLIRS AVLLFTRFVR KLDGFNQEVN IPSVSLSVET VTRSLQDLII YFQPPLEGLG
     HEAKQNSMVA LKNRQNMFQK EGVIDLVLDC IDRLHQYSSA SHFAEAVQSD TGEEWETIVN
     HFYELLAALL RGNRANCANF SGSLDWLISR LERQEASSGV LEVLHCVLVE SPEALNAIKD
     QHIQSVISFL DKHGCNHRVL EVLCSLCVCH GVAVRSNQNL ICDSLLPDRD LLLQTRLVNQ
     VTSMRPNIFL AMGEDSSQYR RWYYELVVDH VNPFLTSEPT HLRVGWACMK GYQPRPTGGE
     GWGGNGVGDD LCSYGFDGLH LWSGCVSRKV SSPFPHLLKD DDVVSCCLDL SIPCISFRVN
     GLPVQGMFEN FNANGLLYPV VSFSAGVKEN KTRVRFLFGG RHGEFRFLPP PGYASCSEAL
     LPKVKLKVQL CQEYILGHGE GKQELIGPLV PVTPVTFTPT PIDISKVVLP PQLEDIREKM
     AENIHELWVM DKIDLGWTHG LVRDEGKKHD PCLVEFSKLP EHERNQNLQM AQDTLRTLLA
     LGFHIGLMDD HAEKHMKYMR LPVKYEQMTG YRPAPVDLSQ VSLSSDHEEA VNLLAEHEHN
     VWARERIKQG WTYGVQQDIK AKQSPYLLPY SLLDERTRRV GRESVREAVC TLLAYGYSLE
     PLNQERTTLS KPCFFSAEKC RVFRPDKSYA VTRGKWYFEY EILTAGNVRV GWARPGCTPD
     KELGSDDQAY VFDGFEAQWY HQGGEPLGRP WLRGDVVGCL VDMDECTMMV TLNGQLLFND
     RGSELAAKDF DIRDGLLPVV SVGVNQVGRL NLGRQVGSLQ YFTVCGLQEG YRPFAVNMAR
     DTALWMSWKQ PQFTSILPDD HYLQVTRVSG SVDSLSSLRV SQCMQPHHGG ESEMGYYRLS
     MSVDCAAVLG SPPGGVLPVA SSALSPSSER KEQEEVDSDF EVLMKSAHSY AGSRDELNHK
     DHSHDKTSRL KQRFMLKKTK PGLVSSNSSA RLLEDVVVDK DNYDHLIQSS RYYYSVRVLP
     GQEPFSVWVG WVTSDFHQHD MTFNTDNVHT VTVTLGDDSG KVHESVKRSN CYMVCAGEAT
     GLSQSRRSTG LEIGCLIDTT TGLLTFTSSG VEMATFYQVE ASTKLFPAVF VKPTTKNMFQ
     FELGRIKNVM PLSSGLLRSQ SRNVTPQCPP RVQVQRLRPA SWTRVPDRAL KVLVDRPDER
     HGWRIQCHEP LQAMILHIPD ENRCVDILEL SELDDLLTFH HNTLLLYCSL CALGNTRVCH
     ALCSHVDQSQ ILYAIQDPYL PGLLRSAFYQ LLFQVFLSSY TTACLMMNHE YIVPMTDQTR
     EITLYPSPIN GGDRQPPEGI SSASCSTSLK PQMHFSTPCF IRSDCMEGAS ALEIACKDSP
     EIPLDVLKNL TVEMLTAAVW AVGQDVRDPA GGNIELLLVP LLRLFYSLLV MGVCRDEDLG
     KILRLMEQGA FARPGTPIEK LEEETSDDEE EQKGVITEES NTVKQGLLQM KLPEAVKLEL
     CHLLSYLCHC QVRHRVEAVI AFSDSFVGQL QENQRFRYNQ VMQALNMSAA LTARKTKEFR
     LPPQEQINML LSFREDTQQE NSPCPVEIQE LLQDFHHLLK THCGIDLAST SEDEEDAEMS
     LKERLLGLVA RVIGRNKSSV DIDGCSSHSP KSLKKMISET MVRWAQESEI EDPELVSAIF
     SLLHRQYQGL RSLMERPLFK AYTIKQSSLE DTMALLSSLG QIRSLLSVRM GKEEERLMIR
     RLGDIMNNKV FYQHPNLMRA LSMHETVMEV MVNVLGEGQI KEITFPKMVA SCCRFLCYFC
     RISRHNQGAL FDHLSYLLEN SSVGLASPSM RGSTPLDVAA ASVMDNNELA LALRESDLEK
     VVQCLAGCGL QSCPMLVAKG YCDIGWNPVE GERYLDFLRF AVFCNGESVE ENAYVVLRLL
     IRRPECFGPA LRGDGGNGLL AAMEEAIKIS EDPSMDGPCT TYQSNRALSV SDSDDDVIHM
     GHAIMTFYSA LIDLLGRCAP EMHLIQGGKG EAIRIRAILR SLIPIQDLQG VISISFQIPS
     VSKDGTLVEP DLSTVFCPDH KAAMVLFLDR VYGVESQSFL LHLLEVGFLP DLQAAVSLDT
     ADLGSTDMAL ALNRYLCTVV LPLLTKYSVL FHDLEDHILL VDSLIQAVYR LSRALSLTKA
     QRDTTEECLL ALCSKLQPPM MQPLLRRLVF DVLHLTDHSK MPLKLLTSHY EQRWKYYSQS
     GRQGEQGCAS EEELYLSTKL FWGVFKALAK KPQMLQLSSL CVQCLSAVAL ALPPDHMEQN
     CLSHIERITS MDTDGHFDSQ PVDTSNVSVP ERLEFVVNKY AEHTHEKWSL EKFVSGWVHG
     EHLCENTKVH PRLKPYRALA EKEKEAYRWA IKETIKTMLA FGWNIERTKE GDAFSMHPCT
     RRVSQSGQLS FEGASTFSPK PVDMSCITLS WDQCAMAEQL AENYHNAWAK TKKLELESKG
     GGSHSLLVPY DTLSAKEKAK FRERAQDVLK FLQLNGYTVW RDRKSVEMDF PAIANCFAYT
     LLQRLLSHTE EAQENLLKLA RGQMSKGERA PHEQPVIFFH KVILPLLEQY VKSHRLYFLS
     ASSSDNRSHA SRKEKEMIAC LFCKLAALVR HRISVFGREA SSVASSLHVL AQALDARTLM
     KSAPESIQTS LHSFFKAAAS DLEMTVETLS ESLVSLPQSR SQLARGVAKV LNYTTSILLP
     TLTSLFLHLG NQNHGVDLLA GGIQVSCYRI LNSLYALGTS SSIYMEGHRS AAGACLAALT
     GAFPVCFLEP DLNQNNPYSI YNMMTATQIK DQGLPDQVED MCPLLPSLGQ ALREVEELAG
     AGAHQAHYIH VAEVTLPMLC SYISHWWNLG PEGQPERPVC TSVVPKHASD LLGNILRIIH
     NHVGASQGDW MKQLAVFSQP VICKVHPELL KSHFLPLMEK LRKRTECVLA EEEQMKAEGG
     DTSDAELQIQ EKFAMLVRDL YAFFPLLIPF VDTHRARWLK DLNPEAEQLF SMVAEVFIFW
     AKSHNFKWEE QNYVVQNEIN NLSFLANNDK TFKDPNTQLD NEKRKMRRKR GCYSTNTSLI
     VALMKRLTPV GLRVCFPSDH SLIILAKNAF SQKTTENEIR DHIFNCVVHL QNQKQEKWES
     KILTELPNQP GYISDAEKTV DRIMEIARVL YYLDQKVSYK VKYVDQVEHP LRNKKPARHT
     VLSKQRKRAV VACLRMTPLY NLPRHRAVNL FLQAYNKSWI SAEEHSFEET LVENLAKRGV
     MEPYVGGRGE EKDVKEGAKP IDPLLQLITL FSRSALTESS KLEIDSLYKS YAAIMAKSCS
     REGEEEEQEV ESFEEKEMEK QKLLYQQARL HCRGASEMVL QTISASKGAI GSMIAPTLKL
     GIAILSGGNA TVQQKMLDYL KEKRDVGFFQ SMSGLMQSCS VLDLNAFERQ NKAEGLGMAT
     DESSGEKVMP DKDLTCDLFR FLQLLCEGHN SDFQNYLRTQ TGNNTTVNII ISTVDYLLRI
     QESISDFYWY YSGKDAIDSQ GQHNFSKAIE VAKQVFNTLT EYIQGPCTGN QQSLAHSRLW
     DAVVGFLHVF AHLQMKLSQD SRQIELLKEL MDLQKDMVVF LLSMLEGNVV NGTTGKQMVD
     MLVESSSNVE MILKFFDMFL KLKDLTSSEA FTEHDPDRQG SISRKDFQKA MENCKHLSQT
     EIHFLLSCME TDDGEIVNYE AFVDRFHEPA KDIGFSITVL LTNLSEHMPN DSRLKTFLEL
     AESVLTYFEP CLGRIEILGS GKRFERVYFE ISEYSRTQWE KPQVKESKRQ FIFDVVNEGA
     EREKMEMFVN FCEDTIFEMQ LAAQISGSNT GERNTGKQVE DKRHLDDQGM FFMIHWWLFL
     STLLSLTNLK TLMKMTLKDI LTSAALFVRF ICMAQVRCIY VLFRSILYVL YIAFVSGGLI
     EGAKRMRISD LLGGILEPTL DEVTEVPSGV DQPRRYSASF SSHRELREIG QIEVDVLSGI
     FGLKLKKEEG RYKLVAQDLT ASLDDLFSTS SRTSASSDIE KHQITQIKDH TTTEEKNEDK
     KMKTEEKKSE KKIGNEKAKA RGRAKIFSNK LKEPQSQQSA LWETIGTHNK SLLNYFARNF
     YNLRLLALFV TFAINFILLF YKVTSFPNLK EEEGMTTSVY GEDLNSDADN SEGRVYFVLE
     KNSGYMEPSL NFLAVAHTII SFCCIIGYYC LKVPLVIFKR EKEVARRLEF DGLYVTKQPP
     EEDIKGQWDR LVINTPSFPS NYWDKFVRRK VMDKYGDFYG CEKISELLGL DKATLDLSSE
     TKTKKRLKRD AAWSALCNSI DMKYQVWKLG VVFTDNSFLY LAWYMTMSFL GHYNNFFFAA
     HLLDIAMGFK TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSDDKDI
     QDMKCNDMLT CYMFHMYVGV RAGGGIGDEI EDPAGDEFEV ERIVFDITFF FFVIVILLAI
     IQGLIIDAFG ELRDQQEQVK EDMETKCFIC GIGSEYFDTV PHGFETHTLQ EHNLANYLFF
     LMYLINKDET EHTGQESYVW KMYQERCWEF FPVGDCFRKQ YEDQLDPYPP VFAVPPSCVP
     SAPLQFLVSS SFPPSLSAVV
//
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