ID I3IW89_ORENI Unreviewed; 1463 AA.
AC I3IW89;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma, 3a {ECO:0000313|Ensembl:ENSONIP00000000879.2};
GN Name=EIF4G3 {ECO:0000313|Ensembl:ENSONIP00000000879.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000879.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000879.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8128.ENSONIP00000062001; -.
DR Ensembl; ENSONIT00000000878.2; ENSONIP00000000879.2; ENSONIG00000000697.2.
DR eggNOG; KOG0401; Eukaryota.
DR GeneTree; ENSGT00940000156454; -.
DR HOGENOM; CLU_001519_2_0_1; -.
DR TreeFam; TF101527; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF23; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 3; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 1099..1221
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1294..1463
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 16..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 750..777
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 277..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..917
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 163114 MW; 5168B83F95EF281B CRC64;
SVFDLQNRSN ETFFQRTQMQ PARPTIPTNT PSIRPGSQAP TAAVYPTNQP IMMTMAPMPF
HSPQAAQYYI PQYRPSTPYV GPPQQYSVQP PGSGTFYPGP GPGEYPAPYP GPPYYPGQSV
YPPSPPIIVP TPQQPPPTKR EKKTIRIRDP NQGGKDITEE IMAGGSGSRN STPPVGPPLL
YTNPTTGMAY SGISSLTSHL CADRILKPFF FLLLDDLPKL EPVAQKSSSP GLVQPDAPLE
RLEANTPASE PSPAPEPELP FPASLARPVT LPVAVANTSE RPSARESTTS ASSHSASSSA
GESKPSLAPP QMPNTDKPLL DAPRTLAASP SLAPKALNGL ADSGTELDTQ AHEPSLQPQA
SAPAYRELSS SETLPSDVRP EVPIAATLSP MAPVAVVPVT LTSSPVPTLP VMLPPGLPPL
VQATAEADEL SKSLDTKDLI SRGGAEAHAG VTDSKTESQQ QALTRKILDC MCFLYMKSSA
LLFLISVYPF FSPLLSSSIL LGCPDLTEPS GKRQYNREFL LGFQFMPACI QKPEGLPPIS
DVVLDKMNQN KLPSRAVDSR VISRGPDFTP AFADFGRQMS GGRSSAIMSI GQRRPPPRKI
IMNVVVNDDV QLKKAENAWK PGMKRESLAE DPEIQKTQEL FRKVRSILNK LTPQKFNQLM
KQVTDLTIDT EERLKGVIDL VFEKAIDEPS FSVAYGNMCR CLATLRVQMT DKPNTTVNFR
KLLLNRCQKE FEKDKVDDVV FERKQKELDS AASVTERERL QEELEEAKDK ARRRSIGNIK
FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK AKPRMDQYFN
QMEKIVKERK TSSRIRFMLQ DVIDLRLHNW VSRRADQGPK TIEQIHKEAK IEEQEEQRKV
HQQLLSKDSK RRPGQREETW NTVPMTKNSR TIDPNKIPKI SKPQMDEKIQ LGPRAQVTWV
KGSSGGAKAS DSDLSRTTGL NRYSALQPTP SPQPSTTPPQ NPDYDSRRTL GSRASTGRER
SDKPLISAAP SARPGPFVRG GSSKELLESQ SPEEPRRDRE REGAEPRRPS VTEDKTEMER
MKPEPVVQTP DRPALSEEEI ERKSKSIIDE FLHINDYKEA IQCVDELDLG SQLHIFVRVG
VESTLERSQI TRDHMGQLFF QLVQQEIVPK AQFYKGFADT LEQADDMAID IPHIWLYLAE
LLSPVLKEGG FSMKELFSEL SKPLLPVGRA GILISEILHL LCKHMSHRTV GSLWRESGLN
WTDILPEGED VQAFILQQKL QFLQSDSSNP EAALPERILS PEEMSRHLER LLLEDMASDE
QIFDWVEANL DETQMSSSPF LRALMTAVCK AAVKDDNTNC RVDTAMIQRR LPVLLKYLNS
DTERQLQALY ALQALIVALD QPPNLLRMFF DCLYDEDVIS EDAFYKWESS KDPAEEQGKG
VALKSVTAFF TWLREAEEES EDN
//
