ID I3IWX6_ORENI Unreviewed; 765 AA.
AC I3IWX6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Solute carrier family 7 member 14 {ECO:0000313|Ensembl:ENSONIP00000001116.1};
GN Name=slc7a14 {ECO:0000313|Ensembl:ENSONIP00000001116.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001116.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001116.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005477362.1; XM_005477305.3.
DR RefSeq; XP_019204753.1; XM_019349208.1.
DR AlphaFoldDB; I3IWX6; -.
DR STRING; 8128.ENSONIP00000001116; -.
DR Ensembl; ENSONIT00000001115.2; ENSONIP00000001116.1; ENSONIG00000000882.2.
DR GeneID; 100692608; -.
DR KEGG; onl:100692608; -.
DR CTD; 566270; -.
DR eggNOG; KOG1286; Eukaryota.
DR GeneTree; ENSGT00940000155893; -.
DR HOGENOM; CLU_007946_15_7_1; -.
DR InParanoid; I3IWX6; -.
DR OMA; QWGATWY; -.
DR OrthoDB; 1421713at2759; -.
DR TreeFam; TF315212; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR029485; CAT_C.
DR PANTHER; PTHR43243:SF25; CATIONIC AMINO ACID TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 629..679
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 468..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 82459 MW; 7121B513A338228A CRC64;
MSGLVGKLDP RRIQWGSTWN TFASRVLRTK PVESMLDSAI SGTSSHGTRL ARVLSTVDLV
SLGVGSCVGT GMYVVSGLVA KEMAGPGVIV SFIIAAVASI LSGVCYAEFG VRVPKTTGSA
YTYSYVTVGE CVAFFIGWNL ILEYLIGTAA GASALSSMAD SLANHTISNF MISHIGTLNG
LGKGEQSYPD LLALLIALLV TVIVALGVKN SVGFNNALNV INLIVWVFMM IAGLFFVNGE
NWDEGRFLPF GWSGVMQGAA TCFYAFIGFD IIATTGEEAK SPNTSIPYAI TASLITCLTA
YVSVSVILTL MVTYDKIDED APLMEMFAIH GCMFAKYIVA VGSIAGLTVS LLGSLFPMPR
VIYAMAGDGL LFKFLAHVSS YTETPVVACV VSGFLASLLS LLVSLRDLIE MMSIGTLLAY
TLVSLCVLLL RYQPEGDIHG FVNFLSEEQN KKRKEGVLAE CEKDACSPTS EADEYGGPPT
NTCGAKNLPS LGDNEMLIGK PDKNAYTASH PNYGTVDMTT GIEAEESEGG LSRRLKKLIG
PRYYTLRIRL GLPGKMDRPT PATGKTVTVC VLLLFIFIFA FCSFIIFGAS TIGEGRWWAL
LLLIFFIIII ALLVIIILQQ PENPKRLPYM APCVPFVPAS AMLVNIYLML KLSAITWIRF
SIWCLVGVLI YFGYGMWNST LEITARENEV HASTYQRYDQ GVDEGFCGFE DDFYPPTTDT
WGAPDGGSGL TSPPVAKPEN DGMPSKSGGR TIANHGLAEE DPMDF
//
