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Database: UniProt
Entry: I3IXW3_ORENI
LinkDB: I3IXW3_ORENI
Original site: I3IXW3_ORENI 
ID   I3IXW3_ORENI            Unreviewed;       784 AA.
AC   I3IXW3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   31-JUL-2019, entry version 51.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=stat3 {ECO:0000313|Ensembl:ENSONIP00000001453};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001453, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000001453}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; AERX01007612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013125075.1; XM_013269621.2.
DR   STRING; 8128.ENSONIP00000001453; -.
DR   Ensembl; ENSONIT00000001452; ENSONIP00000001453; ENSONIG00000001148.
DR   GeneID; 100692602; -.
DR   CTD; 6774; -.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   InParanoid; I3IXW3; -.
DR   OMA; ECASSPM; -.
DR   OrthoDB; 327469at2759; -.
DR   TreeFam; TF318648; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003401; P:axis elongation; IEA:Ensembl.
DR   GO; GO:0061026; P:cardiac muscle tissue regeneration; IEA:Ensembl.
DR   GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
DR   GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
DR   GO; GO:0001736; P:establishment of planar polarity; IEA:Ensembl.
DR   GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR   GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl.
DR   GO; GO:0060252; P:positive regulation of glial cell proliferation; IEA:Ensembl.
DR   GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR   GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
DR   GO; GO:0060042; P:retina morphogenesis in camera-type eye; IEA:Ensembl.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   CDD; cd10374; SH2_STAT3; 1.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR035855; STAT3_SH2.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      581    671       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      140    167       {ECO:0000256|SAM:Coils}.
FT   COILED      194    217       {ECO:0000256|SAM:Coils}.
FT   COILED      271    291       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   784 AA;  89589 MW;  1EB5FF715A007E71 CRC64;
     MAQWNQLQQL ETRYLEQLYH LYSDSFPMEL RQFLAPWIES QDWAYAANKE SHATLVFHNL
     LGEIDQQYSR FLQENNVLYQ HNLRRIKQHL QSKYLEKPMD IARIVARCLW EEQRLLQTAT
     SATQDGQAAH PTGTVVTEKQ QILEHNLQDI RKRVQDMEQK MKMLENLQDD FDFNYKTLKS
     QGELSQDLNG NSQAAATRQK MAQLEQMLSA LDQLRRQIVT EMGGLLTAMD YVQKNLTDEE
     LADWKRRQQI ACIGGPPNIC LDRLETWITS LAESQLQIRQ QIKKLEELQQ KVSYKGDPII
     QHRPALEEKI VDLFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTNKV RLLVKFPELN
     YQLKIKVCID KESGDVAAIR GSRKFNILGT NTKVMNMEES NNGSLSAEFK HLTLREQRCG
     NGGRTNSDAS LIVTEELHLI TFETEVYHQG LKIDLETHSL PVVVISNICQ MPNAWASILW
     YNMLTNHPKN VNFFTKPPVG TWDQVAEVLS WQFSSTTKRG LTIEQLTTLA EKLLGPCVNY
     SGCQITWAKF CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS
     PKPPGTFLLR FSESSKEGGI TFTWVEKDIS GKTQIQSVEP YTKQQLNSMS FADIIMGYKI
     MDATNILVSP LVYLYPDIPK EEAFGKYCRP EAAPEAEMGG DSTSTIQPYL KTKFICVTPC
     PSVFMDLPDS ELLGNGFPGT NSGNTSDLFP MSPRTLDSLM HNEAEATPGH MDSLTLEMDV
     ASPM
//
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