ID I3IYJ9_ORENI Unreviewed; 434 AA.
AC I3IYJ9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Cyclin-A2 {ECO:0000256|ARBA:ARBA00019673};
GN Name=ccna2 {ECO:0000313|Ensembl:ENSONIP00000001689.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001689.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001689.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC (mitosis) transition. {ECO:0000256|ARBA:ARBA00003222}.
CC -!- SUBUNIT: Interacts with the CDK1 protein kinase to form a
CC serine/threonine kinase holoenzyme complex also known as maturation
CC promoting factor (MPF). The cyclin subunit imparts substrate
CC specificity to the complex. {ECO:0000256|ARBA:ARBA00025821}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR RefSeq; XP_003443464.1; XM_003443416.3.
DR RefSeq; XP_005467294.1; XM_005467237.2.
DR AlphaFoldDB; I3IYJ9; -.
DR STRING; 8128.ENSONIP00000001689; -.
DR Ensembl; ENSONIT00000001688.2; ENSONIP00000001689.1; ENSONIG00000001338.2.
DR GeneID; 100711022; -.
DR KEGG; onl:100711022; -.
DR CTD; 890; -.
DR eggNOG; KOG0654; Eukaryota.
DR GeneTree; ENSGT00940000155372; -.
DR HOGENOM; CLU_020695_3_2_1; -.
DR InParanoid; I3IYJ9; -.
DR OMA; HQPFSIH; -.
DR OrthoDB; 5474295at2759; -.
DR TreeFam; TF101002; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:InterPro.
DR CDD; cd20561; CYCLIN_CCNA2_rpt1; 1.
DR CDD; cd20564; CYCLIN_CCNA2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR032447; Cyclin-A_N.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR046965; Cyclin_A/B-like.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR PANTHER; PTHR10177:SF444; CYCLIN-A2; 1.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF16500; Cyclin_N2; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 218..302
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 311..428
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 315..397
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 48432 MW; D496CADD582899C1 CRC64;
MSGANRAQGS AASDYQNQEN VLQRLRGSLK ARPVASENQE NLPPKQAANR TVLGALQNNQ
RNKSQVGGKQ DSTQSLSCKN EDFGKSCFDK PLAKQPAFQI HIDEPDGACI KKPQQAVESI
KAKPTVEESP LAINAVARLR QPLATIEIPS AMDVSFDSPM DMSVVEGEEK PVNVNEAPEY
AAEIHSYLRE MEVKTRPKAG YMKKQPDITN SMRAILVDWL VEVGEEYKLQ NETLYLAVNY
IDRFLSSMSV LRGKLQLVGT AAMLLASKFE EIYPPEVAEF VYITDDTYTK KQVLRMEHLV
LKVLSFDLAS PTINQFLTQY FLQHTVTKQV ESLAMYLGEL SLVDSDPFLK YLPSQTAAAA
YILANTTVTG ASWPKSLNEM TGYSLEDLMP CIEDLHRTYL NAPQHAQQSV REKYKGSKYH
EVSSINAPTK LQLN
//
