ID I3IYN3_ORENI Unreviewed; 403 AA.
AC I3IYN3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Bone morphogenetic protein 4 {ECO:0000313|Ensembl:ENSONIP00000001723.1};
GN Name=bmp4 {ECO:0000313|Ensembl:ENSONIP00000001723.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001723.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001723.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_003442987.1; XM_003442939.4.
DR AlphaFoldDB; I3IYN3; -.
DR STRING; 8128.ENSONIP00000001723; -.
DR Ensembl; ENSONIT00000001722.2; ENSONIP00000001723.1; ENSONIG00000001366.2.
DR GeneID; 100693424; -.
DR KEGG; onl:100693424; -.
DR CTD; 652; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000159502; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR InParanoid; I3IYN3; -.
DR OMA; HEEHMEQ; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF351789; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF165; BONE MORPHOGENETIC PROTEIN 4; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..403
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003671604"
FT DOMAIN 287..403
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 279..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..300
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 46162 MW; 45617A87E0C1FA91 CRC64;
MIPGNRMLMV ILICQVLLGE SNHASLIPEE GKKKVPGLQG RSAAQSHELL RDFEATLLHM
FGLKRRPRPS RSATVPRYLL DLYRLQSGEA EEAGAHDIAF EYPERSASRA NTVRGFHHEE
HMERLHELDD GGPMPIRFMF NLSSIPEDEL LSSAELRLYR HQIDEAIADA ISHDQGLHRI
NVYEVLKAPR PGQLITQLLD TRLVRHNASR WESFDVSPAV LRWTRERLPN YGLAVEVLHL
NQTPRHQGRH VRISRSLHQE PGEDWEQLRP LLVTFGHDGK GHPLTRRTKR SPRQRGRKRN
RNCRRHALYV DFSDVGWNDW IVAPPGYQAY YCHGECPFPL ADHLNSTNHA IVQTLVNSVN
NNIPKACCVP TELSAISMLY LDEHDKVVLK NYQEMVVEGC GCR
//
