ID I3IYP0_ORENI Unreviewed; 871 AA.
AC I3IYP0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=LIM and calponin homology domains 1b {ECO:0000313|Ensembl:ENSONIP00000001730.2};
GN Name=LIMCH1 {ECO:0000313|Ensembl:ENSONIP00000001730.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001730.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001730.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3IYP0; -.
DR Ensembl; ENSONIT00000001729.2; ENSONIP00000001730.2; ENSONIG00000001371.2.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00950000183159; -.
DR HOGENOM; CLU_003242_1_0_1; -.
DR TreeFam; TF332155; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR031865; DUF4757.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15551:SF3; LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR15551; LIM DOMAIN ONLY 7; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF15949; DUF4757; 1.
DR Pfam; PF00412; LIM; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 24..141
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 799..865
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 188..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 374..438
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 721..755
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 188..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 98506 MW; 1F082DA9A1534398 CRC64;
MLYSSCAHAS WQLFFLRGSD QRLPDKSPFF YSHLQAVTGR CFGDKDFRGG LENGILLCEL
LSSIRPGLVK KINRLPTPIA GLDNLSVFLR GCEELGLKGS QLFDPGDLQD TSTRPTAKGS
DGSRKLKNVL ITIYWLGRAA NSCTSYNGPT LDLKEFEGLL SQMRKETEEA ESPKRSIRDS
GYIDCWDSER SDSLSPPRHG REDSFDSLDS FGSRSRQTPS PDVLVARGSS DGRGSDSESD
GAPHRKMPDV RKDDMLARRT SVSEPRTAVP FNQYLPNKSN QSGYLPTPLR KKSNDKEEGG
RKSWSTATSP VGGDRPLRYS HTDSVSDDPQ SVSMIDMRGE EEAALQPHSQ VRHERMHNQY
NKMKEEDDHW QDDLARWKNR RRSISQDLIK KEEERKMMER LMSGDTYTSQ RRRSIKTYRE
IVEDKERREE ELRQAYRKAK TPEEATAILQ RYAQRFSISE AVLERLQLPK LLDRTSPTTP
DPFDSDFNGP MRYLRQQSAP TPKFTSTFEA RIEEFPKEPS SHQRSQIRSR SSEPPSTRAL
SPKPVPLLMP KPYFQARPAG GETWNNKVDG LLRVNGDVGS DDVPTTPESQ GRDSPPHFQA
SPSQSKNSTV DGAVDAPSSE TSLRQSTHAS SREGSPVSTK AKETQDVTEI ASEDTQEVQE
EKVTESTPPS RPTSLPSVRI PIFYTYLHIF VSVPVLPQAK RGDRWSWDPD EERKRQERWQ
QEQERMLQEK YQREQEKLKE EWEKAQKEVA EEERKYHEEV CGGVFCLTAP VMVFNIGDFP
SIHLPTSLSL SYRSVSGKKL CSSCGQPLGK GAAMIIETLS LYFHIHCFKC GVCKGQLGDT
TTGTDVRIRN GLLNCHQCYI RSRSAGQPTT L
//
