ID I3IYS2_ORENI Unreviewed; 417 AA.
AC I3IYS2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Flotillin {ECO:0000256|RuleBase:RU366054};
GN Name=LOC100710678 {ECO:0000313|Ensembl:ENSONIP00000001762.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000001762.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000001762.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterooligomeric complex. {ECO:0000256|RuleBase:RU366054}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU366054}.
CC Endosome {ECO:0000256|RuleBase:RU366054}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR AlphaFoldDB; I3IYS2; -.
DR STRING; 8128.ENSONIP00000048978; -.
DR Ensembl; ENSONIT00000001761.2; ENSONIP00000001762.2; ENSONIG00000001396.2.
DR eggNOG; KOG2668; Eukaryota.
DR GeneTree; ENSGT00560000077232; -.
DR HOGENOM; CLU_038134_1_0_1; -.
DR TreeFam; TF324879; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR031905; Flotillin_C.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF46; FLOTILLIN-2; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF15975; Flot; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366054};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 78..260
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT COILED 207..265
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 417 AA; 46024 MW; 6DFA19C549422973 CRC64;
HTTFTRKGGC CGSDNKTYVV GGWSWAWWLI SDAQRLSLEI MTLQPRCEDV ETAEGVAITV
TGVAQVKVMT EQDLLAVACE QFLGKSVMEI KGVLLQTLEG HLRSILGTLT VEQIYQDRDQ
FAKLVRDVAA PDVGRMGIEI LSFTIKDVYD KLDYLSSLGK TQIAAVQRDA DIGVAEAERD
AGIREAECKK EMMDVKFKAD TKMADSKREL ELQKASFNQE VNARKAEAQL AYELQAAKEQ
QKIRLEEIEI QVVQRKKEIT IEEKEIDRTD KELIATVKRP AEAEAYKMQQ LAEGEKLKKV
LIAQAEAEKI KKIGEAEASS IEAVGKAEAE KMRLKAEAYE QYGDAAKTAL VLEALPKIAS
KVAAPLAKTN EIVILSGEGS RVTGEVNRLL AELPVSVNAL TGVDLSKRGC TSVKLYK
//
