ID I3IZP0_ORENI Unreviewed; 842 AA.
AC I3IZP0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=ADAMTS-like protein 2 {ECO:0000313|Ensembl:ENSONIP00000002080.2};
GN Name=LOC100703496 {ECO:0000313|Ensembl:ENSONIP00000002080.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002080.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002080.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3IZP0; -.
DR STRING; 8128.ENSONIP00000002080; -.
DR Ensembl; ENSONIT00000002080.2; ENSONIP00000002080.2; ENSONIG00000001660.2.
DR eggNOG; KOG3538; Eukaryota.
DR GeneTree; ENSGT00940000164640; -.
DR HOGENOM; CLU_000660_6_1_1; -.
DR InParanoid; I3IZP0; -.
DR OMA; PAHDGTF; -.
DR TreeFam; TF316874; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 7.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF278; ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF A, ISOFORM B; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 6.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 803..841
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT DISULFID 63..104
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 67..109
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 78..94
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 842 AA; 94434 MW; 484914A7DDD89C6E CRC64;
MNFVSSNQTF LQNFLLKMQH VPLQTFFYLL TLMTYFTLLT GLYIFSQEEV FQWWGEWSTW
SSCSRSCGGG VRSQERHCLM QRLSSTQNVN SSCCVGSPKK YQLCSKQPCP STSVSFKQHQ
CSQFNSKAFG RRYYQWIPLY PADYISISNR PCDLQCTTIS GERQLLVPAH DGTSCRDTKN
HGVCIEGMCQ PVGCDGELYS SKTVDRCGVC GGNGTSCQRI SGSYRKALTQ LGYVFITNIP
AGASDIQIIE RHKTENILAL SDEAGYFFFN GNTVFDNPQN FHVAGTVFKY RRPSIVLSDG
LEYIIAQGPT LQGLNVMVYY NLNGKLPHIT YEYTIPLKSR ATAASHHSNL NFTYNDVNVD
VRGDRSISMN HSRGSASVHH DVHDHPDVQL QEEEEEEEEV VWEIQTASPP PAPVDIMVYR
PADVITRVHC DSVSLLPSSN NFDVEPHISL GDMYSWKVSA YAPCSSTCTT GITSTYALCV
RYDGTEVDDR YCDSLTRPEP TQEFCIGKQC PPRWETSGWS ACSRTCGEGV QYRIVRCWKM
LSPGFDSSVY DSLCVSHDLH KPANRKVCHG QSCGPQWEVS EWSECSAHCG SWGIRTREVR
CSMERRQCNE SSRPIESQEC EGQPCDRRWS VSDWGPCSGE CGEGRMVRSV TCRSSGGLVM
SDGQCDQPLR PLAIYPCGDR DCAPHWVEQE WQQCNATCGR GVRQRQVVCA GLEGGVFKEF
PDSSCNQTNK PQMSSSCFRR PCSKWFTTSW SQCSKTCGRG VQVREVKCYQ GEELVTRGHS
CDSALKPEVK QSCEIQSCPT EAPADFCQDK ATANCALVLK VKLCSHWYYR KACCQSCKAP
RA
//
