ID I3IZW2_ORENI Unreviewed; 715 AA.
AC I3IZW2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 67.
DE SubName: Full=Solute carrier family 26 member 6 {ECO:0000313|Ensembl:ENSONIP00000002152.2};
GN Name=slc26a6 {ECO:0000313|Ensembl:ENSONIP00000002152.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002152.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002152.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_005478412.1; XM_005478355.2.
DR AlphaFoldDB; I3IZW2; -.
DR Ensembl; ENSONIT00000002152.2; ENSONIP00000002152.2; ENSONIG00000001718.2.
DR GeneID; 100708344; -.
DR KEGG; onl:100708344; -.
DR CTD; 65010; -.
DR GeneTree; ENSGT01070000253775; -.
DR InParanoid; I3IZW2; -.
DR OMA; FMTICNE; -.
DR OrthoDB; 1067648at2759; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0055081; P:monoatomic anion homeostasis; IEA:Ensembl.
DR GO; GO:0009651; P:response to salt stress; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF196; SOLUTE CARRIER FAMILY 26 MEMBER 6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 93..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 173..200
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 252..270
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 409..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 471..496
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 520..695
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT COILED 559..598
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 715 AA; 78623 MW; B3B36A1B998BD073 CRC64;
MAERRRMSYS VHREVLDEEA MDEMGQKSVS KTSLREKVKK TVRCSGPRMK SCLLGTVPIM
SWLPRYPIKE NALGDLISGI SVGIMQLPQG MAYALLASVP PVFGLYSSFY PVLIYFIFGT
SKHISLGTYA VMSVMIGGVT ERLAPDSDFM TWDNVTNTSI IDTVARDEER VRVAAAVTFI
SGLFQILLGL VQFGFVVTYL SEPLVRGYTT GAAIHVIVSQ LKYTFGISPE RHSGPLSLIY
TVLEICYLLP ETNIGTLVAS IITTLGLIAA KEFNAFLGKR IPIPIPVELV AIIIATVISW
QFDLQQKYGV DVVGVIPSGL QPPVFPDASI FGQVIGDGFA LAVVGYGIAI SLGRIFALKY
GYKVDSNQEL IALGLSNSIG GIFQCFSVSC SMSRTMVQES TGGKTQVAGA LSAVVILFIT
LWIGSLFEDL PKSVLAAIIY VNLHSMMKQF LDIPALWKSN RVDMLVWVAT FILTLLLNPD
IGLAAAIGFS LLTVIFRTQL PKYSMLGRVP ETDIYKPLDE YHQVRQVPGI LIFRSSATLY
FANAEMYQDA LNSKSGFDIT KLLSAKKKLE AKKKRHEKKE AKRVKKELKQ NGVDVNREPN
MEEQNHVSVI EVDPERDPSL PRAIVLDLGP VNFLDTVAVK TLRSIRKDYG EIGVEVVLAG
CQSSVVDNLQ TAGFFNDKVT KSCLFTTVHD AVLYCQSAIT QSQSLENEEI AATHF
//