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Database: UniProt
Entry: I3J044_ORENI
LinkDB: I3J044_ORENI
Original site: I3J044_ORENI 
ID   I3J044_ORENI            Unreviewed;      1507 AA.
AC   I3J044;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-OCT-2019, entry version 51.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000002234};
GN   Name=arhgap5 {ECO:0000313|Ensembl:ENSONIP00000002234};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002234, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000002234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C.P., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
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DR   EMBL; AERX01025914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000002234; -.
DR   Ensembl; ENSONIT00000002234; ENSONIP00000002234; ENSONIG00000001785.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00940000154553; -.
DR   InParanoid; I3J044; -.
DR   OMA; HIDKVND; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 3.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 1.
DR   PROSITE; PS51676; FF; 2.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN      426    480       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      481    547       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      589    762       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      778    943       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1270   1457       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      959    992       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1021   1054       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1136   1261       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    959    981       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1137   1203       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1507 AA;  172189 MW;  C60BFFD7E48C88BD CRC64;
     MAKNKDARPP TFAVSVVGLS GTEKEKGNCG VGKSCLCNRY VRPDADNYYS EHTSVLSTID
     FGGRVVNNDH FLYWGEVSHR GDEGLDYKIQ VIEQTEFIDD QTFLPHRSTN LQPYTKRAAA
     TKLQSAEKLM YICTDQLGLE QDFDQKQMPD GKLNIDAFVL CIDVSKGCNR KFDDQMKFVN
     SLYSQIVKSK KPIVVAATKC DECVDQYLRD LQGFVASKKN LMLIETSARS NVNIELCFNA
     LIQQLDKTRG KPKTVAYLEA YKIQRQLVAS ATDRFEKLMV HSVRDYHTTW KTVMNNLKGQ
     SDYHEFITLE GTKKARNMFT KHIAQLKQEH IKRRREEYLT TLPKTLNNIL NNLDEIEHLS
     WPEAQSVIRN RSDFQYWFVI LENTPWDETD HIDNSDRRIP FDLLDTPDGE RIYHNHVQHL
     LSEKRRGEMK ERFKKTLERV HFITPGQPWE EVMCFVMEDE AYKYITESDR RDVYCRHQQE
     IVERAKEDFQ EMLFEHAELF YDLDLNATPS CDKMSEIHSV LNEEPRYRAL QKLAPDRESL
     LLKHIGFVYH PTKETCLSGQ NCVDLKVEQV LANRLVQLDH GRSNLYYNSA NIDKINLCLL
     GKEGLSQDLA NEIRAQSTDD EYTLDGKIYE LELLPVDVNS TLLFSHTWVT TFKPHGCFCV
     FNSIESLNSI GDCIGRIRAE IAQSRRDRFA QPLPFILILA NQRDSVCKNI PILRHQGQQL
     ANKLQCTFVD IPSGAFPRKF TEFQIKQGLR AVLEGLKHSF EVLAPLPCIK DMSEMDLRIV
     MCAMCWDPFS VDLILSPFLD SHCCSAGQPG QSNTLILDKI IGDSRRRIQV TVLSYHSAIG
     VRKDELVHGY ILVYSAKRKA SMATLRAFLA EVQDVIPVQM VAITDSQADF FENDAIKELM
     TEGEHIATEI AAKFTALYSL SQYHRQTEVF TPFFNEVLEK KPNIESSFLF DSSSRECTTG
     ASEDVFPTSP HSHSPAYNTY YPESDDDNEA PPPYSPIGDD VQLLPTPSER AKYRIDLEGN
     EYPVHSTPVG DHERNHKVPP PVRPKPVLPR PNVKKLDPNL LKTIEAGMRS NRRMPRAPVM
     HAEDVEPSDN YADPVDTLLR PRGFHNDDIY AVPEDAHNRL IKIKNSFGGL HILHGGGEEE
     NGFDRKSQAA RRPSKYKDRS KILFSKTKAY QRRFHSDSDG EETGPATQKK KNRRAHRGSE
     EDPLLSPVDP WKGGIDNPAI TSDPEQEDKK LKKKKTPKTP KESKKPKSSK PPKPLYPPTR
     RTWESNYFGI PLQNLVTPDR PIPLFIDKCV DYIERTGLTT EGLYRVSGNK TDQDNIQKQF
     DQDHSIDFVA MDVAVNAVAG ALKAFFADLP DPLIPYSLHP ELVEAAKIMD YMERLQALRE
     IVKKFPPVNY QVFKYIITHL NRVSQHSKTT LMTADNLSIC FWPTLMRPDF ENKDTLSTTK
     LNQAVIESFI VQSDYFFHGG EVAESSSSEG TPPPHCHNMV EALLPLQLPP PLQPQQIQHT
     LPPDPLI
//
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