ID I3J0Z8_ORENI Unreviewed; 2325 AA.
AC I3J0Z8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A {ECO:0000256|ARBA:ARBA00039688};
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1 {ECO:0000256|ARBA:ARBA00041622};
GN Name=CACNA1A {ECO:0000313|Ensembl:ENSONIP00000002538.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002538.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002538.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1A subfamily. {ECO:0000256|ARBA:ARBA00037936}.
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DR STRING; 8128.ENSONIP00000047905; -.
DR Ensembl; ENSONIT00000002539.2; ENSONIP00000002538.2; ENSONIG00000002030.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000156518; -.
DR HOGENOM; CLU_000540_1_0_1; -.
DR TreeFam; TF312805; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF3; VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1152..1171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1191..1212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1288..1310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1401..1426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1482..1501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1513..1535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1603..1621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1693..1717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1854..1888
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1977..2219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..731
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 816..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2038..2067
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2120..2135
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2136..2176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2177..2217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 326
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 653
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1372
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2325 AA; 262004 MW; 18C754BCE240B2E5 CRC64;
MARFGDEVPA RYGGGPGGGG PGGRGGSRQG GPHGHGHGHG HGHGHGHGHG PPGGPGAQRM
YKQSMAQRAR TMALYNPIPV RQNCFTVNRS LFIFSEDNFV RKYAKKITEW PYPLPCWMIL
ATIIANCIVL ALEQHLPDGD KTPLSERLDD TEPYFIGIFC FESGIKILAL GFAFHKNSYL
RNGWNVMDFV VVLTGILSTV GSQFDLRTLR AVRVLRPLKL VSGIPSLQVV LKSIMKAMIP
LLQIGLLLFF AILMFAIIGL EFYMGKFHKT CFDNITKFPC GVELPSRLCP EDTVCREYWL
GPNYGITQFD NILFAILTVF QCITMEGWTD LLYYSNDASG SAWNWMYFIP LIIIGSFFML
NLVLGVLSGE FAKERERVEN RSEFLKLRRQ QQIERELNGY LEWICKAGSR RRATKNHKSK
AELLNSEEGE GDLGVGSPFA RASLKSSKLE GSTFKRRERR FRFFIRHIVK SQGFYWTVLC
LVGLNTLCVA VVHYDQPEPL SDFLYYAEFI FLGIFLTEMF VKLYGLGRQA YLNSSFNCFD
CIVICGSIFE VLWSIIQPGT SFGISVLRAL RLLRIFKVTK YWASLRNLVV SLLNSMKSII
SLLFLLFLFI VVFALLGMQL FGGQFNFESG TPPTNFDTFP AAIMTVFQIL TGEDWNMVMY
DGIKSQGGVN KGMAFSVFFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEQEEEEAAN
QKIALQKAKE VAEVSPLSAA NLSIAAKEQQ KNHIKGVNKS VWEQRTKELR KQTLASSREA
LYNELDADDR WKVNYSRHIR PDMKTHLDRP LVVDPHENRN NNTNKTTANN SDFCVSQHHP
EHHGQVGGDG GGGSGPPRPP MERGESTESR RSRKSEHHHS SHVRLDATVI PGPGSEDRLP
RRHHHTRTGS RGGGQSEHRK PRSHRKNAED GEDGGGGAGK SGRHKSKGVD GSGEGGEHER
AGNGGEKRSR RSRRGSQTEG EGKDCSIPNL STTRPIQKSL SRQNSQYSED MDNLMNTKLV
SGSTPPSEGR PYPVASHTVT PGFGSALHLA NSGTRGSLVT LDSYGNIGHH RANSVIRLPH
PDYTAVDMPI FPSTNAILQV NKNANTEPLP PPTNDDEEGG EGGPRPMPPY SSMFIFSTTN
PFRRACHYIC TLRYFEMCIL LVIAMSSIAL AAEDPVWPNS PRNDVLRYFD YVFTGVFTFE
MLVKMVDLGL VLHQGSYFRD LWNILDFIVV SGALVAYAYA LAGNSKGKDI STIKSLRVLR
VLRPLKTIKR LPKLKAVFDC VVNSLKNVLN ILIVYLLFMF IFAVVAVQLF KGRFFYCTDE
SKEFERDCRG EYLVYERDNE VRAQKREWKK YDFHYDNVAW ALLTLFTVST GEGWPQVLKH
SVDATYENQG PSPGYRMEMS IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEDYSLE
KNERACIDFA INAKPLTRHM PQNKLSFQYR MWEFVVSPPF EYTIMAMIAL NTIVLMMKYY
GASDTYETVL ANLNIVFTSL FSMECVLKII AFGALNYFKD AWNIFDCVTV LGSITDILVT
ELGNNFINLS FLRLFRAARL IKLLRQGETI RILLWTFVQS FKALPYVCLL IAMLFFIYAI
IGMQLFGNIA IEEDGDSAIN QHNNFRTFVE ALMLLFRSAT GEAWHEIMLA CLGGKECDPK
SGNVDPDCGS QFAYLYFVSF IFFCSFLMLN LFVAVIMDNF EYLTRDSSIL GPHHLDEYVR
IWAEYDPAAC GRIHYKDMYS LLRVIDPPLG LGKKCPHRVA CKRLLRMDLP VADDNTVHFN
STLMALIRTA LDIKIAKGGI DKHQMDAELR KEMMAIWPNL SQKHLDLLVT PHKSTDLTVG
KIYAAMMIME YYRQSKIKRS QALRDEQNRT PLLFQRVEPP TPSQDGGPGL NNLDTSGLFS
LYRNRPVEGG VPESQSWVTA RAQEMSQKVG SWSPEGHPVD GLGSMTNSQT VEMREMGQDG
YSDTEHFPPM EGHGRAASMP RLPGDNQRRK GKQRGSTLST INDSSPMKRS ASSLGHSRSG
RGHRDKGGAD DYNMEHAIPE EGRSSRHGHR RKDRSHRASE RSLCRYTEAD TGLGTDLSTT
TQSGDLTSKD KDRDRDRGRS KDRKHHHHHH HHHGSVDKER YVAERGGEYV HRHSRDRDRE
RERDRRWSRS PSEGRDCVTH RQGSSSVSGS PVPSTSGTST PRRGRRQLPQ TPATPRPHVT
YSPVVRKAMP TPPGGLCRAK FSLQPSAGYP MATVLHHLLH MSTDPHTLGP TRSLLQLGIQ
GVRAKACMNP TVKRRMTIGA SLWGRGWDLT RKKRIQILKE DEPEH
//
