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Database: UniProt
Entry: I3J0Z8_ORENI
LinkDB: I3J0Z8_ORENI
Original site: I3J0Z8_ORENI 
ID   I3J0Z8_ORENI            Unreviewed;      2419 AA.
AC   I3J0Z8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   20-JUN-2018, entry version 41.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a {ECO:0000313|Ensembl:ENSONIP00000002538};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002538, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000002538}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AERX01029786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01029787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000002538; -.
DR   Ensembl; ENSONIT00000002539; ENSONIP00000002538; ENSONIG00000002030.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; EKDCRGK; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    145    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    252       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    309    330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    489    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    520    540       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    615    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    715       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1176   1195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1215   1236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1248   1266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1425   1450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1506   1525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1537   1559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1627   1645       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1717   1741       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1882   1916       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      372    392       {ECO:0000256|SAM:Coils}.
FT   COILED      711    747       {ECO:0000256|SAM:Coils}.
FT   COILED     1021   1041       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2419 AA;  271735 MW;  A1C192C21EDCC8AC CRC64;
     MARFGDEVPA RYGGGPGGGG PGGRGGSSGH GHGHGHGPPG GPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CFTVNRSLFI FSEDNFVRKY AKKITEWPYP LPCVHPFEWM ILATIIANCI
     VLALEQHLPD GDKTPLSERL DDTEPYFIGI FCFESGIKIL ALGFAFHKNS YLRNGWNVMD
     FVVVLTGILS TVGSQFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM IPLLQIGLLL
     FFAILMFAII GLEFYMGKFH KTCFDNITKE IREEFPCGVE LPSRLCPEDT VCREYWLGPN
     YGITQFDNIL FAILTVFQCI TMEGWTDLLY YSNDASGSAW NWMYFIPLII IGSFFMLNLV
     LGVLSGEFAK ERERVENRSE FLKLRRQQQI ERELNGYLEW ICKAEEVILA DDENENEYDA
     GSRRRATKNH KSKAELLNSE EGEGDLGVGM VGSPFARASL KSSKLEGSTF KRRERRFRFF
     IRHIVKSQGF YWTVLCLVGL NTLCVAVVHY DQPEPLSDFL YYAEFIFLGI FLTEMFVKLY
     GLGRQAYLNS SFNCFDCIVI CGSIFEVLWS IIQPGTSFGI SVLRALRLLR IFKVTKYWAS
     LRNLVVSLLN SMKSIISLLF LLFLFIVVFA LLGMQLFGGQ FNFESGTPPT NFDTFPAAIM
     TVFQILTGED WNMVMYDGIK SQGGVNKGMA FSVFFIVLTL FGNYTLLNVF LAIAVDNLAN
     AQELTKDEQE EEEAANQKIA LQKAKEVAEV SPLSAANLSI AAKEQQKNHI KGVNKSVWEQ
     RTKELRKQTL ASSREALYNE LDADDRWKVN YSRHIRPDMK THLDRPLVVD PHENRNNNTN
     KTTANNSDFC VSQHHPEHHG QVGGDGGGGS GPPRPPMERG ESTESRRSRK SEHHHSSHVR
     LDATVIPGPG SEDRLPRRHH HTRTGSRGGG QSEHRKPRSH RKNAEDGEDG GGGAGKSGRH
     KSKGVDGSGE GGEHERAGNG GEKRSRRSRR GSQTEGEGKR MCSHRRKDCS IPNLSTTRPI
     QKSLSRQNSQ YSEDMDNLMN TKLVSGSTPP SEGRPYPVAS HTVTPGFGSA LHLANSGTRG
     SLVTLDSYGN IGHHRANSVI RLPHPDYTAV DMPIFPSTNA ILQVNKNANT EPLPPPTNDD
     EEGGEGGPRP MPPYSSMFIF STTNPFRRAC HYICTLRYFE MCILLVIAMS SIALAAEDPV
     WPNSPRNDVL RYFDYVFTGV FTFEMLVKMV DLGLVLHQGS YFRDLWNILD FIVVSGALVA
     YAYALAGNSK GKDISTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYL
     LFMFIFAVVA VQLFKGRFFY CTDESKEFER DCRGEYLVYE RDNEVRAQKR EWKKYDFHYD
     NVAWALLTLF TVSTGEGWPQ VLKHSVDATY ENQGPSPGYR MEMSIFYVVY FVVFPFFFVN
     IFVALIIITF QEQGDKMMED YSLEKNERAC IDFAINAKPL TRHMPQNKLS FQYRMWEFVV
     SPPFEYTIMA MIALNTIVLM MKYYGASDTY ETVLANLNIV FTSLFSMECV LKIIAFGALN
     YFKDAWNIFD CVTVLGSITD ILVTELGNNF INLSFLRLFR AARLIKLLRQ GETIRILLWT
     FVQSFKALPY VCLLIAMLFF IYAIIGMQLF GNIAIEEDGD SAINQHNNFR TFVEALMLLF
     RSATGEAWHE IMLACLGGKE CDPKSGNVDP DCGSQFAYLY FVSFIFFCSF LMLNLFVAVI
     MDNFEYLTRD SSILGPHHLD EYVRIWAEYD PAACGRIHYK DMYSLLRVID PPLGLGKKCP
     HRVACKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA KGKCLGGIDK HQMDAELRKE
     MMAIWPNLSQ KHLDLLVTPH KSTDLTVGKI YAAMMIMEYY RQSKIKRSQA LRDEQNRTPL
     LFQRVEPPTP SQDGGPGLNN ALPPPEMTET TNSLPVEGGV PESQSWVTAR AQEMSQKVGS
     WSPEGHPVDG LGSMTNSQTV EMREMGQDGY SDTEHFPPME GHGRAASMPR LPGDNQKSPS
     QTCLCVTIND SSPMKRSASS LGHSRSGRGH RDKGGADDYN MEHAIPEEGR SSRHGHRRKD
     RSHRASERSL CRYTEADTGL GTDLSTTTQS GDLTSKDKDR DRDRGRSKDR KHHHHHHHHH
     GSVDKERYVA ERGGEYVHRH SRDRDRERER DRRWSRSPSE GRDCVTHRQG SSSVSGSPVP
     STSGTSTPRR GRRQLPQTPA TPRPHVTYSP VVRKAMPTPP GVAQGRPSAP APAPRRFSPE
     PSQGQGPPPA GLQGGNPHPH ANHPLPPPSQ PQQHNPHPLP PPQPHPVNNP HPQPSRTSPR
     TVHHAPPPTT ALTGPVQGQV QSAAQRRLPN GYRSSSPSTH VHGPPHTGPH KVPPPAGHPR
     GPRKGLHEPY SETEDDDWC
//
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