ID I3J199_ORENI Unreviewed; 713 AA.
AC I3J199;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Catenin alpha like 1 {ECO:0000313|Ensembl:ENSONIP00000002639.2};
GN Name=ctnnal1 {ECO:0000313|Ensembl:ENSONIP00000002639.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002639.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000002639.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
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DR AlphaFoldDB; I3J199; -.
DR STRING; 8128.ENSONIP00000038425; -.
DR Ensembl; ENSONIT00000002640.2; ENSONIP00000002639.2; ENSONIG00000002117.2.
DR eggNOG; KOG3681; Eukaryota.
DR GeneTree; ENSGT01030000234543; -.
DR HOGENOM; CLU_015314_4_0_1; -.
DR TreeFam; TF313686; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 4.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR001033; Alpha_catenin.
DR InterPro; IPR030045; CTNNAL1.
DR InterPro; IPR006077; Vinculin/catenin.
DR PANTHER; PTHR46342; ALPHA-CATULIN; 1.
DR PANTHER; PTHR46342:SF1; ALPHA-CATULIN; 1.
DR Pfam; PF01044; Vinculin; 1.
DR PRINTS; PR00805; ALPHACATENIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 669..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 713 AA; 79501 MW; 9365B941C7017756 CRC64;
MASSPCGNSN FDSGLEIKTR SVEQTLIPLV SQITTLINHK DKPKKSERTL AAIHRVGQAV
SVAVGRFVAV GEAIAAENQE LKDEMGQACF EARRAGDAIA QLTDVGSALP SQLDGRVTVF
SDRTAMVKAA RLLLSSVTKV LVLADRIVIK QIITSRNKVL VTLDHLERVS TFQEFVQIFS
QFGNEMVEFA HLTGDRQNDL KDEKKKARMA AARAVLEKCT MMLLTASKTC LRHPDCESAR
INKDAVFHRM RCALEQVIEI VTEARSSGEN RILPASIYNG IKEFKSGVEC LRENLYFLSP
QSMSSQLEAL VERTEDFTDS AYTSHEQRQA ILGLCQLARQ DTQQLVHAWV EAVCWHMQTE
ATKDMEVAIL KTCQSVSDLR RELHKVAVGR ASDLLKVHGE QLPLRALKAA GAEGNLEEVA
EYSRTLTEQK EQLVETCRLL CHVSGTEPLE ITCIHAEETF HVIGPQIISA AQTLALHPSS
KIAKENLEVF CEAWESQLCD MALLLREIND VFEGRRGDKR PYLSLPRPGV SVTPSVLINE
QTSMAKLGLE LRLLSSDVDT EVEKWEDQEH EIVRQSQSLA SMAYNMYLFT RGEGLLKTTL
DLFHQAEVFF IKLALFLCSS LRTFSSQLVD EEKTVVMTEM EKLLALCQQL QMGAKTPVQG
KTATFQKVTI LHLFVILSVV LSLLPFCNKL NRKVTSTDLD TLLTGSLNMY TNV
//
