ID   I3J1U6_ORENI            Unreviewed;       193 AA.
AC   I3J1U6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Amino-terminal enhancer of split {ECO:0000313|Ensembl:ENSONIP00000002836.2};
GN   Name=LOC100710120 {ECO:0000313|Ensembl:ENSONIP00000002836.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000002836.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000002836.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00005969}.
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DR   AlphaFoldDB; I3J1U6; -.
DR   STRING; 8128.ENSONIP00000076934; -.
DR   Ensembl; ENSONIT00000002837.2; ENSONIP00000002836.2; ENSONIG00000002273.2.
DR   eggNOG; KOG0639; Eukaryota.
DR   GeneTree; ENSGT01030000234519; -.
DR   HOGENOM; CLU_092092_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG23.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF4; TRANSDUCIN-LIKE ENHANCER PROTEIN 2; 1.
DR   Pfam; PF03920; TLE_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          10..125
FT                   /note="Groucho/TLE N-terminal Q-rich"
FT                   /evidence="ECO:0000259|Pfam:PF03920"
FT   REGION          171..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          18..45
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        172..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   193 AA;  21737 MW;  6F3B18EC7707E059 CRC64;
     MFLQASSQQL KFTTSDSCDR IKDEFQFLQA QYHSLKLECD KLASEKSEMQ RHYIMVMIKI
     WNTINHYALL QQAEIVKRLN GICAQVLPYL SQEHQQQVLA AIERAKQVTP PEMNSIIRQQ
     LQAHQLSQLQ GLALPMTPLP LSLSQPTLPA VTTSSGLFSL SSLLASQAQL AKEEKASRDG
     VDSHREEDGD KSD
//