ID I3J2E3_ORENI Unreviewed; 858 AA.
AC I3J2E3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Sodium bicarbonate transporter-like protein 11 {ECO:0000313|Ensembl:ENSONIP00000003033.1};
GN Name=SLC4A11 {ECO:0000313|Ensembl:ENSONIP00000003033.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003033.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003033.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993}.
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DR RefSeq; XP_013126765.1; XM_013271311.2.
DR RefSeq; XP_013126766.1; XM_013271312.2.
DR RefSeq; XP_013126767.1; XM_013271313.2.
DR AlphaFoldDB; I3J2E3; -.
DR STRING; 8128.ENSONIP00000003033; -.
DR Ensembl; ENSONIT00000003034.2; ENSONIP00000003033.1; ENSONIG00000002424.2.
DR GeneID; 100709332; -.
DR eggNOG; KOG1172; Eukaryota.
DR GeneTree; ENSGT00940000154894; -.
DR InParanoid; I3J2E3; -.
DR OMA; PFYWSDW; -.
DR OrthoDB; 1013180at2759; -.
DR TreeFam; TF313630; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR GO; GO:0006820; P:monoatomic anion transport; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF82; SOLUTE CARRIER FAMILY 4 MEMBER 11; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..802
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 858 AA; 97391 MW; 7CBC8F9F35C3FFCA CRC64;
MKSKKEEREM SGVIVNQFAE EAPSTERPKN GYFFQEMELR DGEQDYVEDS PTTNKDHIYD
NEIQISPSDP EGPGFGLLNT TRRYVKPMNF EEEVRAHRDL DGFLAQASIL LDEKAATLDE
VLRRMLTHVV VEGRESWDVD EIMNSLFTDA GRKEINVHLL SETIQGVTAT STGIHYQQSW
LCILSNVRNL QRRHVCITRL ERPQNWGVNC CEARYVILIL APPRTKSTKT AIEVGRTFAT
MFSDISFRQK LLETKNEEEF KQELINHRQQ LSVISDKPVI EEVEDSDPRR GKPLQCIYFF
RFGKGVYDDL RRRLPLYPSD FTDGIIGNDR SLLKYTTTAI FLYIAILLPA IAFGSLNDES
TRGEIDVQKT IVGQSIGGVI YALFAGSPLV IPLTTAPLAI FISVIRGICD DYDLDFDAFY
ACIGLWNSLF LILGGLFNVS LLMKLFKRST EEVIALFISI AFVGDAVKGT IKIFHHYYHG
PILTTTNKTL VLQQINEILD SAKNKTETIL EHHSETGMMS GHAEGHESIF LPESLVLCTR
ERPILCLLLM LGTLWLGYTL YLIKRSPYLN DKIREVVSDC ALPVSVLILS FIGSYLFIDI
QLPVFSVHDG PIFKFPPFEK LSGMNALSAV GLGFLLALLI FIDQNIVISL THVPEHKLLK
GTAFHWDLML TGFINILMSC LGLPWMHAAF PHSSLHARQL AKVEQQVENG HLYTTIVSVK
ETRLTSLVAN ILIGLSMFML PIPLQWIPKP VLYGLFLYIA ATSLDGNQMV DRMTLLLKEQ
TSYPPTHYIR RVPQRKVHYF TGLQIIQLII LCAFGMYPLP YMKMVFPLLM ILLVPVRTSL
LPRMIEAKYL DILDSQYM
//
