ID   I3J2U7_ORENI            Unreviewed;       408 AA.
AC   I3J2U7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=NFKB activating protein {ECO:0000313|Ensembl:ENSONIP00000003187.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003187.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000003187.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NKAP family.
CC       {ECO:0000256|ARBA:ARBA00009313}.
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DR   AlphaFoldDB; I3J2U7; -.
DR   Ensembl; ENSONIT00000003188.2; ENSONIP00000003187.2; ENSONIG00000002546.2.
DR   GeneTree; ENSGT00940000165950; -.
DR   HOGENOM; CLU_032439_1_1_1; -.
DR   InParanoid; I3J2U7; -.
DR   OMA; VERWPND; -.
DR   Proteomes; UP000005207; Linkage group LG2.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   InterPro; IPR040466; NKAP.
DR   InterPro; IPR009269; NKAP_C.
DR   PANTHER; PTHR13087; NF-KAPPA B ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR13087:SF0; NKAP_C DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF15692; NKAP; 1.
DR   Pfam; PF06047; Nkap_C; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          301..398
FT                   /note="NF-kappa-B-activating protein C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06047"
FT   REGION          1..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..97
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..215
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..235
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  47604 MW;  AF3B5B6BE47CAC95 CRC64;
     MPLSDRSSSD GDGESRSPRA RRPRTRSRSR HRSDSRDRSL SPDSFGPKLP KPRNRERERE
     ERERRFKEAR NIRRIRIGSP HRSRSRSRSR SRSRSRSRER HNNNNNSSHN HSNHWSEPPG
     KHGGLKDDYY YEQQRDDAQR QRQEAFIARR LQERERIGEL GCPEVWGYSP RVKEPDSDEF
     TPVEEDEKNS SSESSTEEEK KKKKKKKKKS KKRKNKKHSE DSELESDSDG KMNEKSKKSK
     KKKAKKSRKE SSSDSSSEAS EEEEEEDPNG VLWVEKTSID EHVVGPEAPL THMSQNDRPL
     DFGHALLPGE GAAMAEYVKA GKRIPRRGEI GLTSDEIANF EKSGYVMSGS RHRRMEAVRL
     RKENQIYSAD EKRALASFNQ EERRKRESKI LSSFREMVYR KTKGKEEK
//