ID I3J2W9_ORENI Unreviewed; 782 AA.
AC I3J2W9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Si:ch211-129c21.1 {ECO:0000313|Ensembl:ENSONIP00000003209.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003209.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003209.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; I3J2W9; -.
DR STRING; 8128.ENSONIP00000003209; -.
DR Ensembl; ENSONIT00000003210.2; ENSONIP00000003209.2; ENSONIG00000002563.2.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000165728; -.
DR InParanoid; I3J2W9; -.
DR OMA; TMLMRDD; -.
DR TreeFam; TF352903; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036:SF135; SEMA DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..782
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025421858"
FT TRANSMEM 673..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..472
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 526..610
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 782 AA; 87789 MW; 49043DCC7FF85E7C CRC64;
LLVFSKLAFC FLLWGHFSYE LKLFREEGIY NYSTMLMRED LGVMLLGARE AIYALNMSNI
SVKNATVYWR VTEDKQRDCT YKGKSAEVEC RNYIRTLHRV NDSTMYVCGT NAFSPTCDYL
LTLQGKPEEG KGKCPFDPFQ RYSSLMVGND LYSATSINFL GSEPVVLRSS NLALRTEFKS
SWLNEPNFVY MDFVDESFDS PDGDDDKVYL FFSENAIEYD FYRKVSVSRV ARVCKGDMGG
QRTLQRKWTS FLKARLDCSL SEPSLPSIVQ DVFLLRHKDW RKSVFYAVFT PQSLSQKSAV
CAYSVSAIRD IFNEGKFKTS VAVETSHVKW VMYTGEVPVP RPGACINNMV RKMGMNRSLD
LPDKTLQFIR DRPLMDEAVR PLTGGPLLIT KGAPLTRIVV DSVQGLDGEK YNVMFIGTGK
KRAKAVNYDG EMFIIEEVQL YENHEPISIL RLSSTEGQVY AGSTFGAVQM PVSNCSRYET
CVDCILARDP YCAWDLSTKQ CSSVNTLSPS PDTIQSLKKG DVSQCPPLDP VTAVELVLIP
ENNIQLPCQL HSNLAVADWR FGNHTLHSNN KYYIYSGGLL ILSASETDAG QYSCDSVEEI
NGQKYNQTVA VYRLQLYSDP TTGILPTFGT EVPSTTEAIH KPIHLTPGPV PGLTIDEPLS
PASQNDSGRI THLQVAVAML SLICLSLMGV IFWIWSRGHW ERLKFVQRPS ESEARKQSTE
YRQIPNRTSE VKLLGPESGR PYSANNNHPA VDFKGNGEHH FPPMANISSL DGLGYINDES
EI
//
