ID   I3J3H8_ORENI            Unreviewed;       838 AA.
AC   I3J3H8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=MCF.2 cell line derived transforming sequence a {ECO:0000313|Ensembl:ENSONIP00000003418.2};
GN   Name=MCF2 {ECO:0000313|Ensembl:ENSONIP00000003418.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003418.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000003418.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3J3H8; -.
DR   STRING; 8128.ENSONIP00000079625; -.
DR   Ensembl; ENSONIT00000003419.2; ENSONIP00000003418.2; ENSONIG00000002727.2.
DR   eggNOG; KOG4240; Eukaryota.
DR   GeneTree; ENSGT00940000156974; -.
DR   TreeFam; TF318080; -.
DR   Proteomes; UP000005207; Linkage group LG2.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22826:SF146; PROTO-ONCOGENE DBL; 1.
DR   PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          1..170
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          512..692
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          710..826
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   838 AA;  96169 MW;  29698F192E92AE77 CRC64;
     LRFFFNLLAE VTVPVSMKEV GGYIEKQVAY LSGGRGEDSS VIITLPECSA FSDIPEEALA
     KVFTYLTLIP RQPGVKFIII LDRRLDTWAS IKTALARIAA SFPGNLHLVL VLRPTSFFHR
     TVTDIGFRFS QEDFMLTMPV VMLSSVTDLL RYIDENQLTS EFGGTLDYCH SDWIVLRTAI
     ESFAVTVKDI AQMLQGFGTE LAEPELPEEA KTIECLLEVH TDKYRKLKDA IRSVSKEGRH
     LLSSLETTVK EDDSLWDVKL DWETVQRLLA QLRDMESAFD GFFEKHHLKL HQYLQLLRYE
     QSFQEVRMSS TCLSMFEVTA RAQIIILHGH QLSAGHHYAM ALIMQRCNEL RHYCDTLTAA
     LKTKHTRLLQ THQMLLCLGQ TWCDDAAYLL ANQLVDKFQS KEGAQAALRD IEKLLEGAPS
     MLSSGLDIVT AEYEARNYDL IQHAAVQQMI QNRQACLRKL ADKHVRPVQL VAPRPENTPR
     SKSPLFSPKH GTAQAHRYKP AYFKRRIVIE IENFHVMREL IETERIYVEE LLSVLLGYRA
     EMDNPALSGV LPPILRSKRD ILFGNMPEIY NFHSRVFLQD LEGCLEAPEG VGACFLERKE
     SFQMYESYCQ NKLRSEALWR QFSDCGFFLE CQKKLEHKLG LDSYLLKPIQ RLTKYQLLLK
     ELIKYSTDCE GTSELQGALA AMLDLLKSVN DSMHQIAITG YEGDICELGR VLMQGSFSVW
     ISHKKGPTRM KEMARFKPMQ RHLFLYERAL LLCKRREEHG DGCDKTPSYS FKHCLKMTAV
     GITENVKGDV KKFEIWYSGR EEVYVVQAPT VEVKMAWLNE LRRILTNQQK LLRGLRAT
//