ID I3J3R1_ORENI Unreviewed; 2219 AA.
AC I3J3R1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Fc fragment of IgG binding protein {ECO:0000313|Ensembl:ENSONIP00000003501.2};
GN Name=FCGBP {ECO:0000313|Ensembl:ENSONIP00000003501.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003501.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003501.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000048068; -.
DR Ensembl; ENSONIT00000003502.2; ENSONIP00000003501.2; ENSONIG00000002792.2.
DR GeneTree; ENSGT00950000183155; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 5.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR025615; TILa_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46160; ALPHA-TECTORIN-RELATED; 1.
DR PANTHER; PTHR46160:SF4; VWFD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08742; C8; 5.
DR Pfam; PF01826; TIL; 5.
DR Pfam; PF12714; TILa; 5.
DR Pfam; PF00094; VWD; 6.
DR SMART; SM00832; C8; 5.
DR SMART; SM00214; VWC; 5.
DR SMART; SM00215; VWC_out; 6.
DR SMART; SM00216; VWD; 6.
DR SUPFAM; SSF57567; Serine protease inhibitors; 5.
DR PROSITE; PS51233; VWFD; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 77..256
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 495..679
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 914..1096
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1307..1483
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1693..1853
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2059..2219
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 2219 AA; 242096 MW; 55ECB0EB4F2E8793 CRC64;
LWTMRGDKCV PAAECGCTYE GRYIPAGEAF WADQGCNRWC KCVAGSRQVQ CQEKGCRTGE
ECKVVDGIRK CQAVSFGTCQ ATGDPHYMTF DQKKFNFQGT CVYQLVAVCS KDPELVPFEI
LVQNDHRGSK VVAYTKLVEI KVYSLSIIIT KTHKGQIMVN NELVNLPVTL AEGKISVYKS
GWYAVVTTDF GLKVSFNWDS AVFVTLPSNY MGAVCGLCGN YNGKPQDDLI PKNGNAPVSP
GDFGASWRVA EIPGCVEGCK GVCPDCDINQ KVQYEKDDFC GVIKDAKGPF RDCHAKVDPA
SFFEDCVYDV CLYKGRKDVL CQSITAYTSA CQAAGATVYN WRSAQFLYVM FFMLHTSVNI
SSFSLVLCTF SNGCPLLSMQ CPSNTHYEIC AIACPATCQS LTPPKGCQAQ CVEGCSCDDG
YILSGDACVP LSECGCVYNN RYYRTGEVFY PNGQCVEECN CKKGGEVECK KFTCGPNEKC
KIENGVQKCH PVGKGVCQAA GDPHYLTFDG KKFDFQGTCT YTLSKSCGLE GTHLVEFSVQ
VENEQWDRVV NGKVVSVTKL VAVEVYGFTL IMRNNIYGVL VNGVLNYLPM NLNDGAILVY
QEGNRYVIAT NFGLLVTYDL VYQVTVTVPG NYQGKVCGLC GNYNGDKNDD FAMPNRRLTN
NVNEFGKSWK VTIPSVVCEN GCEGNSCPEC NPAHKAVFSK STYCGIMTDP NGPFAVCHNN
LDPQPYFADC VFDLCASNGD GKVLCDSVAA YAFNCHIAGA DVKNWRTPSF CPMKCPINSH
YEVCAEACSA SCAGLTEIVQ CSSSCTEGCD CDAGFLFNGQ TCVKEIECGC YENGKTYKPG
DVVYEEDCNR KCTCNPGKGL ICEKHFCPQD TKCMVKKGIR ACYNTDPCKD LKCRAQETCR
VEKGEATCIP KYTGTCWAWG DPHYHTFDGY NYDFQGTCKY IISKTCGELD GLVPFLITER
NDNRGNTAVS YVRNVDVFVY NYQITIQKNQ VGQVMVDGEL LNLPVYLGDG KVSVLQRGNT
AEVETDFGLV VSYDWNWYLV IKLPSSYFGL VCGLCGNFNA NVLDEMLNPA GKPVSSVIEW
GKSWLAPKQD KEHPCWDTCE KNCPTCDNDD VKIYKTEAFC GALADKTNGM FQKCHEKVDP
QAFMNSCVYD MCYNKGDKKM LCQALASYSD KCRDEGIIIK NWRTKFGCPM NCQRNSHYED
CASPCQPSCP LTEEKQVCSG TCVETCVCDK GYILSAGVCV PAKTCGCSYQ GRYYKPGQQF
WDDEACHRLC ECDMTLGIVA CREASCSAKE QCTVVDGERA CRPISYATCS ASGDPHYRTF
DGRRYNFQGT CVYQLAGLCS QQPGLVPFKV TVQNDHRGSK AVSYTSTVKF SIYGITLTIS
REYPYKLDGQ LVLLPLNYNN ELMVSLSGWK AVVETAAGIT VTFDWQSTVT VTLPSSYQGA
VCGLCGNYND KAQDDLTMPN GKTTSDEREL GDSWQVASVP GCSSVCQGPW CQACSDSQKK
VYEANKYCGI IADKAGPFKD CHSRVDPTPY MEDCVFDVCQ YQGHHGSVCD AVEVYASACQ
SIGVTIYSWR AESFCPMACP ANSHYSLCAT GCPATCASLT PLTSCHRYCS EGCECDEGYL
LSGDTCVPVK NCGCSYDGQY YQKGDVFYSE DKCAEECTCG DNGAVSCQKA KCRPGEICKL
VNGVKGCYPE GEGKCVASGD PHYISFDGRR FDFQGTCVYV LAKVCDDDKG QLTPFTVTQG
NEKYGNGKVA VTKSVDDELL NLPLSLENGR LKITQEGHNI IVRTAFGLTV LYDTVYYVEV
IVPSTYQGKM CGLCGNYNKN GGDDFILPGG KQAKNVDEFG MAWTVDLPGY MCGGCGGQCP
ECEQAKAVLY GKPDSCGIIS APNGPFKACH SVIDPAVYVS DCVFDVCAVG GDKNTLCNSV
QAYALACQSA GVQIQQWRSN SFCPASCPPH SHYELCADTC SGTCASFITP FGCFPGCFEG
CQCDDGFVFN GVQCVVLEDC GCVYNGRYLM VGQELVDNDC TSKCVCQASG MVKCEKLSCA
SGEVCDIRDG VRGCHLKQGK CVVSRDGQLS SFDGMSGAIG AQGAFQVASL CDESAELWFR
VVVDVRVCNK GASPTVASVY VFFSDTIVAV NSEHVTWVNG RKVSLPSKVT STLSVQISER
ALIIERASAV RVTYSISQEV TVVIHSSLSG KMCGACGNYN NDSKDDMTTI LTFNYLAPC
//
