ID   I3J3W3_ORENI            Unreviewed;      1295 AA.
AC   I3J3W3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=DENN domain-containing protein 3 {ECO:0000313|Ensembl:ENSONIP00000003553.2};
GN   Name=DENND3 {ECO:0000313|Ensembl:ENSONIP00000003553.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003553.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000003553.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   Ensembl; ENSONIT00000003554.2; ENSONIP00000003553.2; ENSONIG00000002833.2.
DR   GeneTree; ENSGT00940000155784; -.
DR   InParanoid; I3J3W3; -.
DR   OMA; EMWAGRI; -.
DR   Proteomes; UP000005207; Linkage group LG22.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          75..501
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REPEAT          1051..1095
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          81..103
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..543
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1295 AA;  146847 MW;  2284546E40F2CF50 CRC64;
     MAELPSGLLE ACVVVGAHSD KLRDIHQLHQ QGKLNGLPLL EAEVLQVHAP PFVSKETNSS
     QVIAPAFSRV QRRRSFIKKK RRDRAAETLS NGEAANRAEV SSTTEDISVP KDLDLIALPE
     LCFPGGLELA SEQKQDSYHF LVFTDMFGNR THGVVVQYYR AVPSCQEGVL QNGHRGSSTK
     ARFYAPFAVC IISKFPYYNA LKDCLSCLLV QLHTARQADF EETVKEFSAK LSLVPLPPPG
     QLHVSFSLRP LQVYLPSRED QDSPVVDIDL HLPFLCFTHT VLLQVLSFLL QEQRLVLFSC
     DWARLTLVAE CLLLYLQPLS WQQPYVPVLA RGMLDFIMAP TAFLMGCHIS HFEEVAAETE
     DLILVNIDDG SIQTSWCETV DLPAIPLVAA ESFTSRAESL QLHFDLELCH LAAGTDANTL
     RSQRRDWQRR LNTQIQNIAL ELVVNIFSGV QDFLSHEHRV FNSEEFLRTR EPADQLFYKK
     VLETHIFHSF LRDRLNRKWD TFSRMEQNTR NLMHRNRGMT ESPRRPPMSE LSRSGYKTYA
     SPDNKLSKRL GASLPNLVQS VSETLPIISP RTVSRKMTPD IGLKSPKKAV KVFRLPEFPP
     PLAYHYVQNY YSDMIASLGK AINATPPEES ALLARYHYLR GLVNTVSNRR LDALEDFQSL
     YKTDSDIFPS QMVKSLVDSL PESERLQADR KAELKRLISR VKRDQERERA GRGNGHEEGA
     IKRFQLPTKY MQLEEFVKCV QESGIVKDQG TIQRLFDALT VGHQKQVSPD LFRVFYTIWK
     ETEAEAQEVC LPTSVLEHIE ANECVFKVSS SVKTSRGVGK IAMTQRRLFL LTDGRPGYVE
     VAQYRDLEEV KVSSAPFMLL RIPGLKLRVR GRKEVFEANL KTETELWNLM VKEMWAGRFT
     ADQHKDPQYM QQALTNALLM DAVVGSLQSS KAIYAASKLA YFDRIKTEVP MMVPKTTAET
     LKHKINPSLE LASPQAVDVL LYTSGQLWVS VNKGKVMVFD ASSWSLTHTC HVGNARLNCM
     LEVDKDQVWM GSEDSVIYII SMVAMVCNRQ LTEHRAEVTG LAVEKDKYSQ KVAYSCSAEG
     TVMVWDVSTL QVKKHFRLSC DRLQSIYTCS GTLWCCSRDR IMEVWRNGSL KRCMNLPEQQ
     KGSTTTFSCA LILPEREEMW SVCADSGEVS IWHIKDCSKP FHRITLQDCT GCYCIMKVKN
     QVWVGGMGRS STKGKVYILD TERYQVLKEL HGHTDKVTGL CSAEDRYVLS GAGKHDGKIA
     IWKGRSILGK HSKEKSNLHH RDMKECKEAQ SLHEV
//