ID   I3J466_ORENI            Unreviewed;       277 AA.
AC   I3J466;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003656.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000003656.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3J466; -.
DR   STRING; 8128.ENSONIP00000003656; -.
DR   Ensembl; ENSONIT00000003657.2; ENSONIP00000003656.2; ENSONIG00000002918.2.
DR   eggNOG; ENOG502QSF7; Eukaryota.
DR   GeneTree; ENSGT00390000001195; -.
DR   HOGENOM; CLU_068697_0_0_1; -.
DR   InParanoid; I3J466; -.
DR   OMA; GMLLNRC; -.
DR   TreeFam; TF329660; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   InterPro; IPR039596; GAS1.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   PANTHER; PTHR16840; GROWTH ARREST-SPECIFIC PROTEIN 1; 1.
DR   PANTHER; PTHR16840:SF8; GROWTH ARREST-SPECIFIC PROTEIN 1-LIKE; 1.
DR   Pfam; PF02351; GDNF; 1.
DR   SMART; SM00907; GDNF; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          47..123
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          137..214
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
SQ   SEQUENCE   277 AA;  30780 MW;  09C889CE7199BF93 CRC64;
     SPGGAKLIQG AKVSGEFLKE LHCMKCWCSA LALLPWVLVA LDAQLICWQA LLRCHNEPEC
     ELAYNQYMTA CEGNIKGTRK QCPSHCISAL IRLNHTRSGP DLETCDCAQD LDCLNAKRAI
     EPCLPRRHPK DAGGIGCMEA RQRCEEDSNC HTSLTAYLSY CGQLFNGRKC SSKCKATIQQ
     MLFIPNGMLL NRCICDGVER PFCEVVKENM SKLCSIGDHG VVSDPTKDYE DPYEYDYPKN
     DKEVDFSENS SASQSLSRGV ASPALCLVPL PHLRLFY
//