ID I3J484_ORENI Unreviewed; 458 AA.
AC I3J484;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Small ArfGAP 1 {ECO:0000313|Ensembl:ENSONIP00000003674.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003674.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003674.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3J484; -.
DR STRING; 8128.ENSONIP00000003674; -.
DR Ensembl; ENSONIT00000003675.2; ENSONIP00000003674.2; ENSONIG00000002934.2.
DR eggNOG; KOG0703; Eukaryota.
DR GeneTree; ENSGT00940000155884; -.
DR HOGENOM; CLU_023062_5_0_1; -.
DR InParanoid; I3J484; -.
DR OMA; KYYDQEA; -.
DR TreeFam; TF313876; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd08839; ArfGap_SMAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR044732; ArfGAP_SMAP1-like.
DR PANTHER; PTHR45705; FI20236P1; 1.
DR PANTHER; PTHR45705:SF8; STROMAL MEMBRANE-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 18..136
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 184..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 49461 MW; CB06F6C8E2920E49 CRC64;
MTTRSEREKA QKLNEQHQAI LSKLLREEDN KYCADCEAKG PRWASWNLGV FMCIRCAGIH
RNLGVHISRV KSVNLDQWTP EQIQSMVDMG NTRARQLYEA HLPENFRRPQ TDQAVEVFIR
DKYERKKYYN KEALATAQVS INNTVCVLQF VSACYCCDAA LPRLEAISCQ CQWLLGGSLI
KEHEKKKEER KKEKDGDKVE RHSNSKVETP LISQNERFDS GSYGSGMDSG SGGAAPIGDE
LDIFGPMVSN PLPSSNNTQQ AQVMHSLSLT FISCLSLQAG CNTQTSPQVD PSTSSSSSSS
TSTTTTAKAE EKKLLSKDSI LSLYASSSVG SQPQSGVYMG QPQMQFTPQG YATAVAGSIP
PTTTMMGGGA VVSGMALPNG GYMSMQQGAM PANQGQNMYS MQQGQWNMGQ MTQQMSGMAL
SGGGPAPAAS SQSGAPGAGW PAVPSPASGQ TLSTQLWK
//
