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Database: UniProt
Entry: I3J491_ORENI
LinkDB: I3J491_ORENI
Original site: I3J491_ORENI 
ID   I3J491_ORENI            Unreviewed;       265 AA.
AC   I3J491;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   SubName: Full=Spi-1 proto-oncogene {ECO:0000313|Ensembl:ENSONIP00000003681.2};
GN   Name=spi1 {ECO:0000313|Ensembl:ENSONIP00000003681.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003681.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000003681.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC       ECO:0000256|RuleBase:RU004019}.
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DR   RefSeq; XP_003445736.1; XM_003445688.4.
DR   AlphaFoldDB; I3J491; -.
DR   STRING; 8128.ENSONIP00000037014; -.
DR   Ensembl; ENSONIT00000003682.2; ENSONIP00000003681.2; ENSONIG00000002940.2.
DR   GeneID; 100690463; -.
DR   KEGG; onl:100690463; -.
DR   CTD; 30117; -.
DR   eggNOG; KOG3805; Eukaryota.
DR   GeneTree; ENSGT00940000159754; -.
DR   HOGENOM; CLU_066451_0_0_1; -.
DR   OrthoDB; 3980839at2759; -.
DR   TreeFam; TF352494; -.
DR   Proteomes; UP000005207; Linkage group LG1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF16; TRANSCRIPTION FACTOR PU.1; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW   Nucleus {ECO:0000256|RuleBase:RU004019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          167..250
FT                   /note="ETS"
FT                   /evidence="ECO:0000259|PROSITE:PS50061"
FT   REGION          125..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        126..144
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  31384 MW;  604C1D9C6F3B355F CRC64;
     MFHPYRMESY LIQPQHTDEI YDPEIYRHQI PEYSYPYVLD PESQAEHWDY HAHPHVHPAE
     FDNLQESNFT ELQNVQALHP SGLLRHDTLR YEAENLLDPN LAAHSHVLQQ PVTFFPRALY
     QPHISQRSSD EEDHGARSPP LEVSDEECLR DRVPYIQAGE MGNKKKIRLY QFLLDLLRNG
     DMKDSIWWVD RDKGTFQFSS KHKEALAHRW GIQKGNRKKM TYQKMARALR NYGKTGEVKK
     IKKKLTYQFS DEVLGKSHLD RKAYI
//
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