ID I3J491_ORENI Unreviewed; 265 AA.
AC I3J491;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Spi-1 proto-oncogene {ECO:0000313|Ensembl:ENSONIP00000003681.2};
GN Name=spi1 {ECO:0000313|Ensembl:ENSONIP00000003681.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003681.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003681.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_003445736.1; XM_003445688.4.
DR AlphaFoldDB; I3J491; -.
DR STRING; 8128.ENSONIP00000037014; -.
DR Ensembl; ENSONIT00000003682.2; ENSONIP00000003681.2; ENSONIG00000002940.2.
DR GeneID; 100690463; -.
DR KEGG; onl:100690463; -.
DR CTD; 30117; -.
DR eggNOG; KOG3805; Eukaryota.
DR GeneTree; ENSGT00940000159754; -.
DR HOGENOM; CLU_066451_0_0_1; -.
DR OrthoDB; 3980839at2759; -.
DR TreeFam; TF352494; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF16; TRANSCRIPTION FACTOR PU.1; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 167..250
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 125..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 31384 MW; 604C1D9C6F3B355F CRC64;
MFHPYRMESY LIQPQHTDEI YDPEIYRHQI PEYSYPYVLD PESQAEHWDY HAHPHVHPAE
FDNLQESNFT ELQNVQALHP SGLLRHDTLR YEAENLLDPN LAAHSHVLQQ PVTFFPRALY
QPHISQRSSD EEDHGARSPP LEVSDEECLR DRVPYIQAGE MGNKKKIRLY QFLLDLLRNG
DMKDSIWWVD RDKGTFQFSS KHKEALAHRW GIQKGNRKKM TYQKMARALR NYGKTGEVKK
IKKKLTYQFS DEVLGKSHLD RKAYI
//