ID I3J4I3_ORENI Unreviewed; 1469 AA.
AC I3J4I3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Kinesin family member 13A {ECO:0000313|Ensembl:ENSONIP00000003773.2};
GN Name=KIF13A {ECO:0000313|Ensembl:ENSONIP00000003773.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003773.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003773.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR Ensembl; ENSONIT00000003774.2; ENSONIP00000003773.2; ENSONIG00000003013.2.
DR GeneTree; ENSGT00940000157508; -.
DR HOGENOM; CLU_001485_29_2_1; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF5; -; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM01052; CAP_GLY; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 1..283
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1383..1425
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 564..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 298..340
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 564..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1301
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1469 AA; 164267 MW; A2644AD4E591448F CRC64;
MTVSSQEVVF KCLGEGILEN AFQGYNACIF AYGQTGSGKS FSMMGNGEQP GLIPRLCCSL
FERVHRETNE GHSFKVEVSY MEIYNEKVRD LLDPKGSRQS LKVREHKVFG PYVDGLSQLA
VTSFEDIEVL MSEGNKSRTV AATNMNEESS RSHAVFSIIV TQTLYDLQSG NSGEKVSKMS
LVDLAGSERV SKTGAAGERL KEGSNINKSL TTLGCVISAL ADQSAGKGKA KFVPYRDSVL
TWLLKDNLGG NSKTAMIATV SPAADNYEET LSTLRYADRA KRIVNHAVVN EDPNARIIRE
LREEVEKLKV QLSQAESMKA PELKEKLQES EKLIQEMTVT WEEKLRKTEE IATERQKQLE
SMGISLETSG IKVGEDKCFL VNLNADPALN ELLVYYLKEH TRVGADTSQD IQLFGIGIQP
EHCVLELCPD GDVTLMPIGN ARTCVNGTMI DSLVHLWHGD RILWGNNHFF RINLPKRKRR
DRLKELERAS PRESFVEADI ETASEASSEQ DYTYEFAQME VIMKTLGNND PMQNVVQVLE
KQYLEEKRTA LEEQRMMYER ELESLRQQLS PEKTSQHHRS SSDRLTFSTH APHSKLRLWT
EERDELFRQS LSRLREQVVK ANTLVREANF LAEEMNKLTD YQVTLQIPAA NLSANRKRGA
IVSEPAIQVR RKGKGTQVWT IEKLENKLVD MRDHYRDWKE ASSKHCDPFY EAQENHNLIG
VANIFLECLF HDVKLQYAVP IISQQGEVAG RLHVELMRVS GAVPERLDAT GLPLNLSNFV
FCQYTFWEHG EPTVAPPMVS PDRPSPRSPD AQFTVQFDHC KDYVVHVTDE FLEFISDGAL
AIEVWGHRCA GNGRSLWELD ALEAKTQTLR DRWSEVSRRI ELWIAIQELN EQGEYASVEL
QPGKDISTGG VFQLRQGHSR RLQVSVKPVQ NSGTLPLLVE AVLSVSIGCV SARSTKLQRP
LDSYQEEDLN CVRERWSDAL IKRREYLDEQ IKKIINKQEK SEEDIEREAR LVEQWVGLTE
ERNAVLVPAP GSGIPGAPAD WTPPAGMEAH IPVLFLDLNA DNLTVNEQLT GPHAAGVNSI
LPKEHGSQFF YLPIIRHSDE EVSAVCSWDS SIHDSVHLNR VTSPNERIYL IIKATVQLSH
PASMELVLRK RIAVNIYNKQ SFTQSLKRRM SLKNMLYSCG VTYEIVSNIP KASEEPEERE
TLALMAARGD SEETQDGETY IEKYTRGVLE VENILSLERL RQAVTVKEAL AAKGRHLRRS
ISTPNVQQVI KEITHCMSSP CPAQINPAAS VPPPQSPSPL TPLPTATSSA PTLRAGGEPP
IQEPAQGDLP HGSPCPSPNP SSAEPSGDSS GDESTPVAQL PDWMAPGEQV WVGKRRGTVH
YVGGVEFAKG IWIGVKLDMA VGKHNGTVQG RVYFRCPPGH GVFVKPSRLT RGPPSMDKDM
FSGELQGSEG GPQIPFGFPS YYLFDHSSL
//
