ID I3J4L6_ORENI Unreviewed; 511 AA.
AC I3J4L6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Homeobox-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000003806.2};
GN Name=LOC100699346 {ECO:0000313|Ensembl:ENSONIP00000003806.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000003806.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000003806.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_013127683.1; XM_013272229.2.
DR RefSeq; XP_013127725.1; XM_013272271.2.
DR AlphaFoldDB; I3J4L6; -.
DR STRING; 8128.ENSONIP00000003806; -.
DR Ensembl; ENSONIT00000003807.2; ENSONIP00000003806.2; ENSONIG00000003040.2.
DR GeneID; 100699346; -.
DR eggNOG; ENOG502QQSR; Eukaryota.
DR GeneTree; ENSGT00940000154928; -.
DR HOGENOM; CLU_052355_1_0_1; -.
DR InParanoid; I3J4L6; -.
DR OMA; THKPSYM; -.
DR OrthoDB; 5399075at2759; -.
DR TreeFam; TF320327; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR040363; HMBOX1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14618:SF4; HOMEOBOX-CONTAINING PROTEIN 1 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR14618; HOMEODOX-CONTAINING PROTEIN 1 HMBOX1; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..37
FT /note="HNF-p1"
FT /evidence="ECO:0000259|PROSITE:PS51937"
FT DOMAIN 142..238
FT /note="POU-specific atypical"
FT /evidence="ECO:0000259|PROSITE:PS51936"
FT DOMAIN 263..338
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 265..339
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 44..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 55727 MW; 9CC44D198D4BB274 CRC64;
MFQQCEEPRF TIEQIDLLQR LRRTGITQAE VLHALDTLDH LDRQHGHKLT HKPSYVPPSS
SSTVAASSSM TSTATQTSFP NNRLSLSPNN NFDTTSPPLP VPVASPNTIT AVVPNGLVAV
TNGKLSPPRF PLGVVSATVT TPGYAFEASE EDIDVDEKVE DLMRRDSAVI KEEIKSFLAN
RRISQAVVAQ VTGISQSRIS HWLLQQGSDL SEQKKRAFFR WYQLEKTNPG ATLAMRATPL
ALEEVMDWNQ APPTFGSAPG GFRLRRGSRF TWRKECLAVM EGYFNDNQYP DEAKREEIAT
ACNAVIQKPG KKLSDLERVT SLKVYNWFAN RRKDIKRRAN IEAAILESHG IEVQSPGGQS
NSDDVDGNDF PDQGCEVSLF DKRASARQFS FSRADLSSPT QVPTLLPSWF SALGRGGVSG
QRATSLIGRS LISGAVPQME GSRLTGVSWS PPSPSLQDEP TVHSALSEPQ DPVSLEKAAA
VSDSSPAVTN QGDGAGCSMG NDIKTETLED D
//
